Korean J Otolaryngol-Head Neck Surg.  2006 Apr;49(4):468-471.

Photodynamic Therapy(PDT) for Early Glottic Cancer which was Recurred after Initial Treatment Modality

Affiliations
  • 1Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine, Cheonan, Korea. pschung@dankook.ac.kr

Abstract

Photodynamic therapy (PDT) is a method used to treat cancer early by irradiating laser with suitable wavelength after injection of a photosensitizer. We introduce the result of PDT for treating an early glottic cancer where initial treatment modality had failed. We tried PDT for 2 patients: one had recurrence after laser cordectomy (T1b) and the other after radiation therapy (T2). Photogem 2 mg/kg was injected intravenously and laser irradiation was performed after 48 hours. We irradiated the lesion site using diode laser (630 nm) delivered through 5 mm cylindrical fiber tip. The energy density, as determined by the depth and site of the lesion, were 138 J/cm and 204 J/cm, respectively. Patient with T1b is alive with no evidence of disease for 46 months post-PDT follow up. Patient with T2 developed chondritis at the subglottis but improved after hyperbaric oxygen therapy and several surgical debridement. After 4 months, tumor recurred at both vocal folds and was managed with total laryngectomy. PDT is a new treatment modality with advantages of good voice quality, short period of admission, and less rate of morbidity and may be another useful salvage option.

Keyword

Laryngeal neoplasm; Photodynamic therapy; Photosensitizer

MeSH Terms

Debridement
Follow-Up Studies
Humans
Hyperbaric Oxygenation
Laryngeal Neoplasms
Laryngectomy
Lasers, Semiconductor
Photochemotherapy
Recurrence
Vocal Cords
Voice Quality
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