Korean J Otolaryngol-Head Neck Surg.  2005 Jun;48(6):741-744.

Glutathione S-Transferase P1 Polymorphism in Patients with Allergic Rhinitis

Affiliations
  • 1Department of Otolaryngology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
  • 2Department of Otolaryngology-Head & Neck Surgery, Gil Medical Center, Gachon Medical School, Incheon, Korea. enthwang@hanmail.net
  • 3Department of Molecular Biology Lab, Gil Medical Center, Gachon Medical School, Incheon, Korea.

Abstract

BACKGROUND AND OBJECTIVES
Genetic factors play a role in the etiology of allergic rhinitis. The glutathione S-transferase (GSTP1) is one of the detoxifying enzymes for oxidative stress. The purpose of this study is to examine Polymorphisms of whether there is an association between some alleles of GSTP1 genes and allergic rhinitis. SUBJECTS AND METHOD: Patients with allergic rhinitis were selected on the basis of the following criteria: 1) watery rhinorrhea, sneezing, nasal obstruction and/or itching for longer 3months and 2) positive reaction at the allergic skin prick test for DP, DF allergen and 3) positive reaction at specific IgE RAST for DP, DF allergen. GSTP1 gene polymorphisms in exon5 (Ile105Val) were analyzed by polymerase chain reaction (PCR) with restriction fragment length polymorphisms (RFLP) in 149 patients with allergic rhinitis and 156 healthy control subjects. RESULTS: In allergic rhinitis, Ile105/Ile105 were 106 cases (71.1%), Ile105/Val105 were 42 cases (28.2%), Val105/Val105 were 1 case (0.7%) and in normal controls, Ile105/Ile105 were 100 cases (64.1%), Ile105/Val105 were 45 cases (28.8%), Val105/Val105 were 11 cases (7.1%)(p=0.004). CONCLUSION: Genetic polymorphism of Val105/Val105 in GSTP1 may be protective genotypes in allergic rhinitis.

Keyword

Allergic rhinitis; Glutathione S-transferase P1(GSTP1); Polymorphism

MeSH Terms

Alleles
Genotype
Glutathione Transferase*
Glutathione*
Humans
Immunoglobulin E
Nasal Obstruction
Oxidative Stress
Polymerase Chain Reaction
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Pruritus
Rhinitis*
Skin
Sneezing
Glutathione
Glutathione Transferase
Immunoglobulin E
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