Korean J Otolaryngol-Head Neck Surg.  2004 Jun;47(6):545-548.

A Study of Prevalence between Allergic Rhinitis and CCR5 Gene Polymorphism Study of a Korean Population

• Lee JH
• Choi TW
• Oh CK
• Park SY
• Yoon SW
• Kim JJ

Abstract

BACKGROUND AND OBJECTIVES
CC chemokine receptor (CCR5) is characteristic of the Th 1 phenotype, the receptor of RANTES, MIP-1alphaand MIP-1beta. The receptor of CCR5 delta32 (a 32 bp deletion in the CCR5 gene, mutant type) results in the production of a non-functional receptor. Given the potential importance of CCR5 in allergic inflammation, we hypothesized that individuals carrying the CCR5 delta32 allele would show a reduced prevalence of allergic rhinitis. SUBJECTS AND METHOD: Blood samples for genetic analysis were obtained from 187 individuals with allergic rhinitis and from 278 healthy subjects without atopic diseases. Polymerase chain reaction-based assay for the CCR5 gene polymorphism was used for genotyping. RESULTS: We could not find the CCR5 delta32 homozygotes and heterozygotes at all in neither of the controls nor allergic rhinitis Korean patients. CONCLUSION: Since the CCR5 delta32 allele frequency did not deviate from that in the healthy control population, it is unlikely that this allele influences predisposition to allergic rhinitis in Koreans.

Keyword

Receptors, CCR5; Perennial allergic rhinitis; Koreans; Polymorphism

MeSH Terms

Alleles
Asian Continental Ancestry Group
Chemokine CCL4
Chemokine CCL5
Gene Frequency
Heterozygote
Homozygote
Humans
Inflammation
Phenotype
Prevalence*
Receptors, CCR
Receptors, CCR5
Rhinitis*
Chemokine CCL4
Chemokine CCL5
Receptors, CCR
Receptors, CCR5