Korean J Otolaryngol-Head Neck Surg.  2003 Jun;46(6):508-512.

Preliminary Results of Mitomycin-C Application in the Treatment of Laryngeal Stenosis and Granuloma

Affiliations
  • 1Department of Otorhinolaryngology, The Institute of Logopedics & Phoniatrics, Yonsei University College of Medicine, Yong Dong Severance Hospital, Seoul, Korea. hschoi@yumc.yonsei.ac.kr

Abstract

BACKGROUND AND OBJECTIVES
Mitomycin-C is an antibiotic, antineoplastic agent that inhibits DNA and protein synthesis, and fibroblast proliferation. It has been successfully used in adjunction to glaucoma surgery, dacryocystorhinostomy, pterygium surgery, and middle meatal antrostomy. The purpose of this study is to evaluate the efficacy and safety of intraoperative Mitomycin-C application as an adjunct therapy in the endoscopic treatment of laryngeal stenosis and granulation. MATERIALS AND METHOD: A total 13 subjects, of whom 2 had anterior glottic web, 4 posterior laryngeal stenosis, and 7 laryngeal granuloma were included. All underwent stroboscopy and were treated with endoscopic laryngomicrosurgery with CO2 laser. Then, 1 cc of 0.4 mg/mL Mitomycin-C was directly applied for 4 minutes on the surgical site. The patients' symptoms were assessed, and the size of the airway was graded on a scale of I (< or =50%) to IV (total occlusion) after a mean follow-up period of 5 months. The recurrence of the laryngeal granuloma was checked. RESULTS: There was a significant improvement in postoperative symptoms in the group of posterior laryngeal stenosis. Two with tracheotomy underwent decannulation. The postoperative size of airway was markedly increased and restenosis was not noted. There was only one case of recurrence in the granuloma group. CONCLUSION: According to these preliminary results, it is suggested that application of Mitomycin-C can be used as a beneficial adjunct therapy in the endoscopic COc laser excision for laryngeal stenosis and granuloma.

Keyword

Mitomycin-C; Laryngeal stenosis; Glottic web; Granuloma

MeSH Terms

Dacryocystorhinostomy
DNA
Fibroblasts
Follow-Up Studies
Glaucoma
Granuloma*
Granuloma, Laryngeal
Laryngostenosis*
Lasers, Gas
Mitomycin*
Pterygium
Recurrence
Stroboscopy
Tracheotomy
DNA
Mitomycin
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