Korean J Pathol.  1999 Nov;33(11):1024-1032.

Talc Deposition in Lipoma: A Pathologic and Mineralogic Study

• Kim JR
• Lim HS
• Cheong HK
• Kim JY
• Sakai K
• Hisanaga N

Abstract

Three cases of lipomas associated with heavy talc deposits are reported in local inhabitants near a fiber glass factory. Pathologic and mineralogical analysis by polarizing microscopy, scanning and transmission electron microscopy with energy dispersive X-ray analysis and X-ray diffraction of mass were done. Simultaneously, we performed an epidemiological survey and a mineralogical study of disposed fiber glass from waste site and ground water. All tumors consisted of mature fat tissue containing an abundant birefringent talc fibers and particles under polarized light. The concentrations of the fibers were 494.7, 6.7 and 50.7 million fibers per gram of dry tissue. The fibers were needlelike with rectangular fractured ends, up to 17 micrometer in length and 0.5 micrometer in diameter. EDX and X-ray diffraction analysis of the fibers showed that 71 to 100% of the fibers were magnesium silicate, talc. We also identified magnesium silicate fibers in the fiber glass from the waste site and in the ground water which were similar to talc fibers in lipomas,. We concluded that fibrous talc, a component of fiberglass waste, might be associated with the development of lipomas via unknown exposure route.

Keyword

Lipoma; Environmental exposure; Talc, Fiber glass; Foreign body

MeSH Terms

Environmental Exposure
Foreign Bodies
Glass
Groundwater
Lipoma*
Magnesium
Microscopy
Microscopy, Electron, Transmission
Nerve Fibers, Myelinated
Silicates
Talc*
X-Ray Diffraction
Magnesium
Silicates
Talc