Korean J Pediatr Gastroenterol Nutr.
2000 Mar;3(1):105-109.
Hepatocellular Carcinoma Following Vertical Transmission of Hepatitis B Virus in a Child with X-linked Agammaglobulinemia
- Affiliations
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- 1Department of Pediatrics, St. Columban's Hospital, Mokpo, Korea.
- 2Department of Pediatrics, Chonnam National University Medical School, Kwangju, Korea.
- 3Department of Pediatrics, University of Ulsan College of Medicine, Asan Nedical Center, Seoul, Korea.
Abstract
- X-linked agammaglobulinemia (XLA) is a primary inherited B-cell immunodeficiency. The prevalence of neoplastic disease in patients with XLA is approximatedly 0.7%. The most frequent tumor is lymphoreticular malignancy. We report a case of hepatocellular carcinoma (HCC) in a 13-year-old boy with XLA, after probable maternal transmission of hepatitis B virus. The authors consider that the vertical transmission of hepatitis B virus might play an important role in the development of HCC in a child with XLA who could not eliminate hepatitis B virus effectively.
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