Effects of Preservation of the Lamina Propria of the Maxillary Sinus Mucosa on Mucosal Regeneration in Experimentally Induced Maxillary Sinusitis with Polyposis in Rabbits

Hong, Soon Kwan; Kim, Chong Nahm; Park, Mi Hyang; Min, Yang Gi

Abstract

BACKGROUND AND OBJECTIVES: It remains unclear whether the lamina propria (LP) of the sinus mucosa should be preserved in the management of the paranasal sinuses with severely diseased mucosa. The aim of this study is to evaluate the effects of preservation of the LP of the maxillary sinus (MS) mucosa on mucosal regeneration in maxillary sinusitis with polyposis in rabbits.
MATERIALS AND METHODS
Maxillary sinusitis with polyposis was induced in 180 of the 190 MSs in 95 rabbits and, from these, 10 MSs were used as control. After 4 weeks, the ostia were reopened and 180 MSs were divided into 3 groups according to the following different procedures on the MSs; preservation of the whole mucoperiosteum without removal of polyps and polypoid mucosa (group A), complete removal of the whole mucoperiosteum (group B), and preservation of part of the LP and the periosteum with removal of polyps and polypoid mucosal surface (group C). Each of the experimental groups was explored after 0, 2, 4, 6, 8 and 12 weeks, respectively. Changes of mucociliary transport (MCT) speed, ciliary beat frequency (CBF), and inflammation score in histopathology were evaluated.
RESULTS
Eight and/or 12 weeks after the procedures, there were significant improvements in MCT speed, CBF and inflammation score of the group C, compared with those of the group A and/or the group B.
CONCLUSION
Preservation of the LP and the periosteum with removal of only polyps and polypoid mucosal surface may be more beneficial to mucosal regeneration than preservation or complete removal of the whole mucoperiosteum including polyps and polypoid mucosa in the surgical management of maxillary sinusitis even though the MS mucosa was severely diseased.