Korean J Otolaryngol-Head Neck Surg.  1997 Feb;40(2):286-291.

Expression of Fos Protein in Brainstem Vestibular Nuclei of Rat - I. Off-axis Centripetal Acceleration -

  • 1Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Korea University, Seoul, Korea.


Fos, the protein product of c-fos gene, has been known to be rapidly expressed in neurons following various external and internal stimuli. This experiment was performed to determine whether off-axis centripetal acceleration cause a proper stimulation to the otolith organ and the afferent neural pathway from the otolith organ can be mapped by detection of expressed Fos protein. Therefore we performed on-axis and off-axis centripetal acceleration stimulation to experimental animals and investigated Fos expression immunohistochemically. In results, there were no expression of Fos protein following on-axis centripetal acceleration, whereas in the medial, descending vestibular nuclei and y-group of the off-axially stimulated animal, we could find strong expression of Fos protein.


Off-axis centripetal acceleration; Fos protein; Vestibular nuclei
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