Korean J Obstet Gynecol.  2012 Nov;55(11):870-873. 10.5468/KJOG.2012.55.11.870.

Endometrial cancer six years after colon cancer in Lynch syndrome: Single institution case in Korea

• Bae SY
• Kim MK
• Kim BG

• KMID: 2274159
• DOI: http://doi.org/10.5468/KJOG.2012.55.11.870

Abstract

Here, we present a case of endometrial cancer six years after colon cancer in a Lynch syndrome patient at one institution. A 36-year-old Asian woman underwent surgery for colon cancer and six years later she underwent surgery for endometrial cancer. Based on a family history of cancer, she underwent genetic testing, including gene sequencing, after she contracted the colon cancer. A microsatellite instability test was performed and showed an unstable final result. Gene sequencing (MSH2) revealed a mutation at c.2649 T>G (p.1883M). However, her follow-up was not normal. In the second operation, immunohistochemistry showed that her endometrium stained negatively for MSH2, consistent with the previous test. As far as we know, this is a first case of metachronous cancer sin Korea regarding Lynch syndrome in single institution. It is important for enterocolonists and gynecological oncologists to screen effectively to reduce the mortality and costs associated with these genetic malignancies.

Keyword

Lynch syndrome II; Endometrial neoplasms; Colonic neoplasms

MeSH Terms

Adult
Asian Continental Ancestry Group
Colon
Colonic Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
Contracts
Endometrial Neoplasms
Endometrium
Female
Follow-Up Studies
Genetic Testing
Humans
Immunohistochemistry
Korea
Lynch Syndrome II
Microsatellite Instability

Figure

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  Fig. 1 Family history of cancer.

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  Fig. 2 Gene sequencing result.

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  Fig. 3 Immunohistochemistry of endometrium (H&E, ×200).

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