Korean J Obstet Gynecol.  2012 Nov;55(11):870-873. 10.5468/KJOG.2012.55.11.870.

Endometrial cancer six years after colon cancer in Lynch syndrome: Single institution case in Korea

  • 1Division of Gynecologic Oncology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.
  • 2Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. minkyukim@skku.edu


Here, we present a case of endometrial cancer six years after colon cancer in a Lynch syndrome patient at one institution. A 36-year-old Asian woman underwent surgery for colon cancer and six years later she underwent surgery for endometrial cancer. Based on a family history of cancer, she underwent genetic testing, including gene sequencing, after she contracted the colon cancer. A microsatellite instability test was performed and showed an unstable final result. Gene sequencing (MSH2) revealed a mutation at c.2649 T>G (p.1883M). However, her follow-up was not normal. In the second operation, immunohistochemistry showed that her endometrium stained negatively for MSH2, consistent with the previous test. As far as we know, this is a first case of metachronous cancer sin Korea regarding Lynch syndrome in single institution. It is important for enterocolonists and gynecological oncologists to screen effectively to reduce the mortality and costs associated with these genetic malignancies.


Lynch syndrome II; Endometrial neoplasms; Colonic neoplasms
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