Korean J Obstet Gynecol.  2008 Jun;51(6):642-649.

Risk factors for ectopic pregnancy after fresh non-donor in vitro fertilization and embryo transfer

Affiliations
  • 1Fertility Center of CHA General Hospital, Pocheon CHA University, Department of Obstetrics and Gynecology, College of Medicine, Seoul, Korea. obdoc1970@naver.com

Abstract


OBJECTIVE
To find risk factors for ectopic pregnancy among women who conceived after fresh non-donor in vitro fertilization and embryo transfer (IVF-ET).
METHODS
A total of 2,326 cycles conceived after fresh non-donor IVF-ET between January 2002 and December 2005 were studied with regard to patient factors, and factors related to the ART procedures through review of their medical chart. Risk factors in ectopic pregnancy were assessed by using chi-square test and multivariate logistic regression analysis.
RESULTS
Of 2,326 pregnancies of fresh non-donor IVF-ET cycles, 135 (5.8%) were ectopic pregnancies. Most of ectopic pregnancies were tubal type (79 cases, 58.5%) and combined type (40 cases, 29.6%). Most of ectopic pregnancies (87.4%) were treated by laparoscopic surgery. In comparison with clinical pregnancy group, estradiol level checked on human chorionic gonadotrophin (hCG) injection day for final follicular maturation and mean number of oocytes retrived were higher in ectopic group. respectively, (2,228.9 vs. 1,906.9 pg/ml, p=0.022; 13.8 vs. 11.6, p=0.001). In univariate analysis, the risk for ectopic pregnancy was increased among women with tubal factor infertility (odds ratio [OR] 1.7, 95% confidence interval [CI] 1.20-2.35) and, decreased among women with male factor infertility (OR 0.7, 95% CI 0.47-0.94) and use of intracytoplasmic sperm injection (ICSI) (OR 0.7, 95% CI 0.50-0.98). However, in multivariate logistic regression analysis, only tubal factor was an independent predictor for ectopic pregnancy.
CONCLUSIONS
Tubal factor infertility is the main risk factor for ectopic pregnancy following fresh non-donor IVF-ET.

Keyword

IVF; Ectopic pregnancy; Risk factor; Tubal factor

MeSH Terms

Chorion
Embryo Transfer
Embryonic Structures
Estradiol
Female
Fertilization in Vitro
Humans
Infertility
Laparoscopy
Logistic Models
Male
Oocytes
Pregnancy
Pregnancy, Ectopic
Risk Factors
Sperm Injections, Intracytoplasmic
Estradiol
Full Text Links
  • KJOG
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr