Korean J Obstet Gynecol.  2008 May;51(5):555-562.

The expression of p57(kip2) in normal ovaries and ovarian tumors

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine Konyang University, Daejeon, Korea. sklee@kyuh.co.kr
  • 2Assisted Reproductive Technology Clinic, College of Medicine Konyang University, Daejeon, Korea.
  • 3Department of Pathology, College of Medicine Konyang University, Daejeon, Korea.
  • 4Department of Obstetrics and Gynecology, Washington University School of Medicine in St. Louis, Missouri, U.S.A.

Abstract


OBJECTIVES
The purpose of this study is to investigate the expression of CDK (Cyclin dependent kinase) inhibitor, p57(kip2) in human ovarian corpus luteum, benign and malignant ovarian tumors.
METHODS
46 women undergoing laparoscopic surgery or laparotomy for ovarian tumors were enrolled. Total 46 formalin-fixed, paraffin-embedded sections of corpus luteum, benign and malignant ovarian tumors were stained by immunohistochemistry for expression of p57(kip2).
RESULTS
p57(kip2) was stained in theca cell of growing follicle but not induced in human corpus luteum. There was the expression of p57(kip2) in mature teratoma, immature teratoma and endometrioma but not in epithelial ovarian tumors.
CONCLUSIONS
These results showed that p57(kip2) expression may be not important in luteinization of the ovary and seemed not to play a role in development of epithelial ovarian tumors. However, it may involve pathogenesis of mature teratoma, immature teratoma and endometrioma.

Keyword

p57(kip2); Lutenization; Teratoma; Ovarian tumor
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