Korean J Obstet Gynecol.  2007 Apr;50(4):587-593.

Maternal serum highly sensitive C-reactive protein as a predictive marker of tocolytic success in preterm labor patient

Affiliations
  • 1Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. yhkim522@yumc.yonsei.ac.kr

Abstract


OBJECTIVE
The purpose of this study was to evaluate whether maternal serum highly sensitive C-reactive protein (hsCRP) could be use as a marker of prediction of tocolytic success in preterm labor pregnancy, and was more useful in comparison with other inflammatory factors.
METHODS
Maternal serum white blood cell (WBC) count, C-reactive protein (CRP), and hsCRP were determined in 87 patients in preterm labor and 68 controls. Preterm labor group was divided into tocolytic success group (n=44) and failure group (n=43). The levels of maternal serum WBC count, CRP, and hsCRP were evaluated using receiver operating characteristic (ROC) curve and area under the curve (AUC) to evaluate the relative value as prediction marker of tocolytic success in two preterm labor groups. The data were analyzed using student t-test.
RESULTS
There was no significant difference for maternal age, body mass index (BMI), gestational age, and parity between normal group and preterm labor group. But, WBC count and hsCRP were significantly higher in preterm labor group in comparison to normal group (p<0.001). In preterm labor group, there was no significant difference in maternal age, BMI, gestational age, and parity between tocolytic success group and failure group. But, WBC count, CRP, and hsCRP were significantly lower in tocolytic success group. In the prediction of tocolytic success, the AUCs of WBC count, CRP, and hsCRP were 0.65, 0.77, and 0.82, respectively.
CONCLUSION
This study showed that serum levels of hsCRP may be used as a marker of prediction of tocolytic success in preterm labor pregnancy.

Keyword

Highly sensitive C-reactive protein; Preterm labor; Tocolytic success; Predictive marker

MeSH Terms

Area Under Curve
Body Mass Index
C-Reactive Protein*
Female
Gestational Age
Humans
Leukocytes
Maternal Age
Obstetric Labor, Premature*
Parity
Pregnancy
ROC Curve
C-Reactive Protein
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