Korean J Obstet Gynecol.  2005 Feb;48(2):334-341.

Correlation of adenoassociated virus type 2 and high-risk human papillomavirus type 16 and 18 infection in the cervix of Korean women

Affiliations
  • 1Department of Obstetrics and Gynecology, College of Medicine, College of Medicine, The Catholic University of Korea. ahnws@catholic.ac.kr
  • 2Catholic Research Institutes of Medical Science, The Catholic University of Korea.
  • 3Department of Statistics, College of Medicine, The Catholic University of Korea.
  • 4Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Bucheon, Korea.
  • 5Department of Obstetrics and Gynecology, College of Medicine, Kyungbook National University, Taegu, Korea.
  • 6Department of Obstetrics and Gynecology, College of Medicine, Chonnam National University, Gwangju, Korea.
  • 7College of Pharmacy, Seoul National University, Korea.
  • 8BMS Korea Research Center, Seoul, Korea.

Abstract


OBJECTIVE
Previous studies were showed that adenoassocited virus (AAV) infection was had negative effects on human papillomavirus (HPV) infection and that the cervical cancer cell growth is inhibited by AAV infection. We detected of AAV 2 and high-risk HPV infection and researched correlation with AAV 2 and HPV in cervical cell.
METHODS
Cell of normal cervix (49 persons), infected HPV cervix (45 persons), cervical intraepithelial neoplasm (CIN) I (31 persons), II (20 persons), III (35 persons), and invasive cancer (30 persons) were investigated by PCR using AAV-2 and HPV type 16 and 18 specific primers.
RESULTS
AAV 2 was detected in 8 out of 49 normal cervix (16.3%), 2 out of 45 infected HPV cervix (4.4%), 3 out of 31 CIN I (9.7%), 4 out of 20 CIN II (20%), 8 out of 35 CIN III (22.8%), and 3 out of 30 invasive cervical cancer cases (30%). However, HPV 16 was detected in 5 out of 49 normal cervix (10.2%), 20 out of 45 infected HPV cervix (44.4%), 13 out of 31 CIN I (42%), 11 out of 20 CIN II (55%), 19 out of 35 CIN III (54.3%), and 21 out of 30 invasive cervical cancer cases (70%). HPV 18 was detected in 6 out of 49 normal cervix (12.2%), 18 out of 45 infected HPV cervix (40%), 16 out of 31 CIN I (51.6%), 10 out of 20 CIN II (50%), 22 out of 35 CIN III (62.8%), and 13 out of 30 invasive cervical cancer cases (43.3%).
CONCLUSION
AAV 2 was detected in normal and infected HPV cervix, CIN (I, II, III) and invasive cervical cancer. As compared to normal, CIN I and CIN II, suggesting significant correlation between AAV 2 and HPV type 16. Further, researches continue to be done relationship to AAV 2 and HPV infection in cervix.

Keyword

Adenoassocited virus; Human papillomavirus; Cervical intraepithelial neoplasm; Cervical cancer; PCR

MeSH Terms

Cervical Intraepithelial Neoplasia
Cervix Uteri*
Female
Human papillomavirus 16
Human papillomavirus 18
Humans*
Polymerase Chain Reaction
Uterine Cervical Neoplasms
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