Korean J Obstet Gynecol.
2004 Jun;47(6):1171-1178.
Expression of Angiopoietin-1 and Angiopoietin-2 mRNA in Eutopic and Ectopic Endometrium
- Affiliations
-
- 1Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea.
- 2Department of Obstetrics and Gynecology, College of Medicine, Ewha Woman's University, Seoul, Korea.
Abstract
OBJECTIVE
To investigate the mRNA expression of Angiopoietin (Ang)-1 and Ang-2 in ectopic and eutopic endometrium from women with or without endometriosis throughout the menstrual cycle.
METHODS
Total RNA was extracted and reverse transcribed into cDNA. The expression of Ang-1 and Ang-2 was examined by quantative competitive PCR (QC PCR) and each result was analyzed by Kruskal- Wallis analysis and Mann-Whitney U-test.
RESULTS
The expression of Ang-1 mRNA was statistically significantly higher in endometrium of follicular phase from women with endometriosis compared to that from normal ones in the follicular phase. Endometriotic tissues expressed significantly lower Ang-2 mRNA compared to endometrium from women without endometriosis.
CONCLUSION
We suggested that the expression of Ang-1 mRNA could be associated with the pathogenesis of endometriosis and might have a role as neovascularizaton and survival of ectopic endometrium.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Expression of Angiopoietin-1 and -2 and Tie-2 mRNA in Uterine Endometrial Cancer
- Hypertension, Vascular Rarefaction and Angiopoietin-1
- The expression of angiopoietin-1, angiopoietin-2, Tie-2 and vascular endothelial growth factor mRNA in normal ovary, benign ovarian cyst, and epithelial ovarian cancer
- Expression of EGF mRNA and protein in eutopic and ectopic endometrial tissues of patients with endometriosis
- Expression of Osteopontin in Eutopic and Ectopic Endometrial Tissues in Endometriosis
