Korean J Obstet Gynecol.  2003 Aug;46(8):1594-1598.

A Case of Alpha-Fetoprotein producing Sertoli-Leydig Cell Tumor

  • 1Department of Obstetrics and Gynecology, College of Medicine, Hallym University, Chunchon, Korea.


The Sertoil-Leydig cell tumor (SLCT) is gonadal tumor of sex-cord type, similar to that seen in the various phase of testicular development in the male. It is the most common type of all virilizing ovarian tumors and account for less than 0.5% of all ovarian tumors. A 26-year-old woman had an ovarian SLCT associated with an elevated level of serum AFP. The tumor had a heterologous element of intestinal-type mucinous epithelium, retiform and intermediately differentiated tubules of the Sertoli cell, and AFP-producing Leydig cells. After surgery, the serum AFP level of the patient fell to the normal range. We experienced a case of AFP producing SLCT, so we present it with a brief review of literature.


Sertoli-Leydig cell tumor; Alpha-Fetoprotein; Ovarian neoplasms
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