Korean J Obstet Gynecol.  2003 Jul;46(7):1325-1331.

The Effect of NK-1 Receptor Antagonist on the Enhanced Response to Bradykinin by Mustard Oil Treatment of the Rat Uterus

• Na JY
• Park JW
• Hong SK

Abstract

OBJECTIVE
To find out wheather the substance P takes part in the pain mediating system of uterus, and to ascertain the role of substance P in the hypersensitivity of hypogastric nerve to bradykinin during the uterine inflammation.
METHODS
The uterus has two sensory innervations, which are the hypogastric nerve and the pelvic nerve. Since the hypogastric nerve is known to show increased sensitivity to bradykinin, a pain mediator, when the uterus is in inflammatory state, the hypogastric nerve recording was done for electrophysiological study of uterine pain-mediating mechanism in female SD rats (200-250 g). NK1 receptor antagonist (L-703,606) was injected through uterine artery before injecting bradykinin while uterus was under inflammation.
RESULTS
The NK-1 receptor antagonist (L-703,606) decreased the spontaneous nerve impulse during inflammation, and it also decreased the hypersensitivity of the hypogastric nerve to bradykinin during the uterine inflammation.
CONCLUSION
Substance P mediates the pain sense of hypogastric nerve, and it also plays a role in increased sensitivity of hypogastric nerve to bradykinin while uterus is in inflammatory state.

Keyword

Substance P; Bradykinin; Uterine inflammation

MeSH Terms

Action Potentials
Animals
Bradykinin*
Female
Humans
Hypersensitivity
Inflammation
Mustard Plant*
Negotiating
Rats*
Receptors, Neurokinin-1*
Substance P
Uterine Artery
Uterus*
Bradykinin
Receptors, Neurokinin-1
Substance P