Korean J Obes.  2016 Mar;25(1):5-9. 10.7570/kjo.2016.25.1.5.

Early Biomarkers Predicting Successful Weight Loss after Anti-obesity Intervention

Affiliations
  • 1Family Medicine Clinic and Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.
  • 2Department of Medical Education, Pusan National University Medical School, Yangsan, Korea. saylee@pnu.edu

Abstract

Weight loss of as little as 5-10% can result in improvement in cardiovascular and metabolic risks associated with obesity. Despite use of any weight loss intervention, whether pharmacological or non-pharmacological, approximately 50% of obese patients achieve a modest weight loss of 5% of initial body weight. Thus, it might be useful to predict weight-loss effectiveness at the beginning of treatment for establishment of an individually tailored strategy to effectively treat obesity. This review provides an overview of emerging biomarkers as pre-treatment predictors of weight loss or weight regain after intentional weight reduction in obese patients. Results suggests that leptin, aspartate transaminase, and circadian rhythm play roles as pre-treatment predictors of weight-loss effectiveness; retinol-binding protein 4, total testosterone, and sex hormone-binding globulin as predictors of weight regain; and fasting glucose as a predictor of successful long-term weight loss after Roux-en-Y gastric bypass.

Keyword

Obesity; Biomarker; Prediction; Treatment; Efficacy

MeSH Terms

Aspartate Aminotransferases
Biomarkers*
Body Weight
Circadian Rhythm
Fasting
Gastric Bypass
Glucose
Humans
Leptin
Obesity
Sex Hormone-Binding Globulin
Testosterone
Weight Loss*
Aspartate Aminotransferases
Glucose
Leptin
Sex Hormone-Binding Globulin
Testosterone
Full Text Links
  • KJO
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr