Cancer Res Treat.  2001 Aug;33(4):318-323.

Expression Pattern of p27 Protein in Primary Gastric Lymphomas

• Go JH

Abstract

PURPOSE: To investigate the expression pattern of p27 protein in primary gastric lymphomas.
MATERIALS AND METHODS
Immunostaining for the p27 protein was performed in 16 cases of low grade mucosa-associated lymphoid tissue (MALT) lymphomas and 16 cases of high grade B-cell lymphomas of the stomach.
RESULTS
All low grade MALT lymphomas were positive, however all high grade lymphomas were negative forp27 protein. Most of the monocytoid cells in the low grade lymphoma were unstained.
CONCLUSION
Loss of p27 protein expression is well correlated with histologic grade and appears to be associated with the high grade transformation seen in primary gastric lymphomas.

Keyword

Lymphoma; Stomach; p27 protein

MeSH Terms

Lymphoid Tissue
Lymphoma*
Lymphoma, B-Cell
Lymphoma, B-Cell, Marginal Zone
Stomach