Cancer Res Treat.  2010 Sep;42(3):176-179.

Recurrent and Metastatic Trichilemmal Carcinoma of the Skin Over the Thigh: A Case Report

• Yi HS
• Sym SJ
• Park J
• Cho EK
• Ha SY
• Shin DB
• Lee JH

Abstract

Trichilemmal carcinoma (TC) is an uncommon cutaneous neoplasm that develops from the external root sheath of the hair follicle. It is considered to be a low-grade carcinoma with low metastatic potential. Local recurrence and metastasis are rare after surgical excision. We report here on a case of metastatic TC in the skin over the thigh, and this tumor was treated with cisplatin and cyclophosphamide combination chemotherapy.

Keyword

Skin neoplasms; Lymphatic metastasis; Palliative care

MeSH Terms

Cisplatin
Cyclophosphamide
Drug Therapy, Combination
Hair Follicle
Lymphatic Metastasis
Neoplasm Metastasis
Palliative Care
Recurrence
Skin
Skin Neoplasms
Thigh
Cisplatin
Cyclophosphamide

Figure

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  Fig. 1 The trichilemmal carcinoma is composed of several epithelial aggregations arranged in various growth patterns, including solid, lobular and trabecular growth patterns (skin, H&E, ×40).

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  Fig. 2 The epithelial aggregation exhibits, at least focally, the feature of outer root sheath differentiation, including neoplastic cells with abundant, clear cytoplasm, and the cells show prominent atypia and a high mitotic activity (skin, H&E, ×400).

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  Fig. 3 The metastatic lymph node demonstrates neoplastic cells with prominent atypia (lymph node, H&E, ×40).

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  Fig. 4 The initial abdomino-pelvic CT scan demonstrates multiple, various sized, enlarged lymph nodes in the aortocaval, paraaortic, portocaval (A) and left inguinal areas (B).

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  Fig. 5 The follow-up CT scan after four cycles of chemotherapy shows the decreased size of retroperitoneal (A) and left inginal lymph nodes (B).

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