Ann Dermatol.  2009 Aug;21(3):277-280. 10.5021/ad.2009.21.3.277.

Langerhans Cell Histiocytosis Presenting as Brown Lichenoid Patches

• Kwon H
• Lee JH
• Kim SK
• Park YL
• Lee JS
• Cho MK

• KMID: 2266290
• DOI: http://doi.org/10.5021/ad.2009.21.3.277

Abstract

Langerhans cell histiocytosis (LCH) is related diseases characterized by proliferation of Langerhans cell with involvement of bone, skin, lung and other organs. LCH usually occurs in childhood and are presented as multiple small papules or eczematoid lesion mostly. We report a 50-year-old man with 3 brown lichenoid patches on left dorsal foot. He was diagnosed pulmonary LCH 5 years ago. Typical LC cells on skin lesion and CD1 complex positive staining confirm the diagnosis of LCH. We consider brown lichenoid patches may be a previously unreported cutaneous presentation in cutaneous or multisystem LCH.

Keyword

Langerhans cell histiocytosis

MeSH Terms

Foot
Histiocytosis, Langerhans-Cell
Humans
Lung
Middle Aged
Skin

Figure

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  Fig. 1 Three brown lichenoid patches on left dorsal foot.

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  Fig. 2 Lobular consolidation at left basal segment of left lower lobe in chest CT.

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  Fig. 3 (A) Dense epidermotropic infiltration of histiocytes (H&E, ×100). (B) Many histiocytes consist of indented eccentric nucleus and abundant cytoplasm (H&E, ×400). (C) The histiocytes stain with the CD 1a complex (×200). (D) The histiocytes stain with the S-100 protein (×100).

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