Ann Dermatol.  2013 Feb;25(1):99-103. 10.5021/ad.2013.25.1.99.

Cutaneous Metastasis of Gallbladder Adenocarcinoma in a Patient with Chronic Lymphocytic Leukemia: A Case Report and Review of the Literature

• Tanriverdi O
• Meydan N
• Barutca S
• Kadikoylu
• Sargin G
• Tataroglu
• Culhaci N

• KMID: 2265980
• DOI: http://doi.org/10.5021/ad.2013.25.1.99

Abstract

Skin metastasis of primary gallbladder tumors is extremely rare with a reported incidence of 0.7~9% and it usually involves the thorax, abdomen, the extremities, neck, head region, and scalp. Cutaneous metastasis may occur synchronously or metatochronously. In the present case, the patient had chronic lymphocytic leukemia, which was being treated with an alkylating agent (chlorambucil) when the patient developed skin metastasis from gallbladder adenocarcinoma during post- cholecystectomy follow-up. Given the fact that secondary malignancies occur in chronic lymphocytic leukemia; this clinical setting warrants attention. We aimed to discuss secondary malignancy in chronic lymphocytic leukemia patients and gallbladder adenocarcinoma with skin metastasis, based on a review of the literature and the presented case.

Keyword

Chronic lymphocytic leukemia; Gallbladder neoplasms; Neoplasms metastasis

MeSH Terms

Abdomen
Adenocarcinoma
Cholecystectomy
Extremities
Follow-Up Studies
Gallbladder
Gallbladder Neoplasms
Head
Humans
Incidence
Leukemia, Lymphocytic, Chronic, B-Cell
Neck
Neoplasm Metastasis
Scalp
Skin
Thorax

Figure

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  Fig. 1 (A) Poorly differentiated primary adenocarcinoma in excised gallbladder tissue (H&E, ×200). (B) Poorly differentiated primary adenocarcinoma in excised gallbladder tissue (stained with cytokeratin 20, ×200).

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  Fig. 2 Gallbladder adenocarcinoma metastasis in a skin lesion (H&E, ×200).

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  Fig. 3 (A) Erythematous, thin peduncle cutaneous metastatic lesion measuring 0.5~1 cm in the scalp. (B) Erythematous, thin peduncle cutaneous metastatic lesion measuring 2~2.5 cm in the submandibulary region.

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