Ann Dermatol.  2014 Feb;26(1):129-132. 10.5021/ad.2014.26.1.129.

Biological Effects of Femtosecond-Terahertz Pulses on C57BL/6 Mouse Skin

Affiliations
  • 1Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. oskwon@snu.ac.kr
  • 2Institute of Dermatological Science, Seoul National University College of Medicine, Seoul, Korea.
  • 3Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
  • 4Pohang Accelerator Laboratory, POSTECH, Pohang, Korea.
  • 5Department of Physics and Astronomy, Seoul National University College of Natural Sciences, Seoul, Korea.

Abstract

No abstract available.


MeSH Terms

Animals
Mice*
Skin*

Figure

  • Fig. 1 Histological observations on the back skin of C57BL/6 mice exposed to the femtosecond-Terahertz (fs-THz) beam for 1 hour (H&E; ×200 and ×400). Skin samples were biopsied at 1 and 24 hours after exposure.

  • Fig. 2 Gene expression in the femtosecond-Terahertz (fs-THz)-irradiated mouse skin. The back skin of C57BL/6 mice (sham, n=4; fs-THz, n=5; A~D) and BALB/c nude mice (sham, n=3; fs-THz, n=4; E~F) were exposed to the fs-THz beam for 1 hour. Skin samples were biopsied either at 1 and 24 hours after exposure of C57BL/6 mice or at 12 and 36 hours after exposure of BALB/C nude mice. Real-time quantitative polymerase chain reaction was used for gene expression survey: (A) substance P, (B) calcitonin gene-related peptide, (C, E) transient receptor potential vanilloid1 (TRPV1), (D, F) TRPV4. Results were expressed as mean±standard error of the mean. *p<0.05, compared to the nonirradiated sham group.


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