Ann Dermatol.  2014 Aug;26(4):554-556. 10.5021/ad.2014.26.4.554.

Giant Congenital Melanocytic Nevus with Proliferative Nodules Mimicking a Congenital Malignant Melanoma

Affiliations
  • 1Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. miumiu@amc.seoul.kr

Abstract

No abstract available.


MeSH Terms

Melanoma*
Nevus, Pigmented*

Figure

  • Fig. 1 A giant congenital nevus with proliferative nodules on lower abdomen, genitalia, anus and lower legs.

  • Fig. 2 (A) Histopathology of the proliferative nodule showed a proliferative dermal nodule in a giant congenital nevus (H&E, ×40). (B) Congenital nevus cells formed nests at the dermo-epidermal junction and upper dermis (H&E, ×200). (C) Melanocytic cells within the dermal nodule were more cellularlarger, more heavily pigmented and predominantly epithelioid cells, showing low-grade cytologic atypia and minimal pleomorphism (H&E, ×400). The immunohistochemical stains showed a positivity for (D) HMB45 (×100), (E) Melan A (×100), (F) SOX-10 (×100), and (G) Ki-67 (×100).


Reference

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