Ann Dermatol.  2010 May;22(2):196-198. 10.5021/ad.2010.22.2.196.

A Case of Kikuchi's Disease Presenting with Unique Facial Involvement

Affiliations
  • 1Department of Dermatology, College of Medicine, Korea University, Seoul, Korea. hjsongmd@medimail.co.kr
  • 2Department of Dermatology, Asan Medical Center, Seoul, Korea.

Abstract

Kikuchi's disease (KD), or histiocytic necrotizing lymphadenitis, is a rare, self-limited lymphadenopathy, typically in young women, that usually remits spontaneously and does not recur. KD is clinically characterized by cervical lymphadenopathy and a high fever. Extranodal involvement (skin, arthritis, meningitis) rarely occurs. When KD is involved in a skin lesion, it presents with various shapes, but rarely manifests with symmetrically distributed, erythematous, firm nodules only on the face. In this report, we describe a patient with KD and unique skin manifestations.

Keyword

Cutaneous involvement; Histiocytic necrotizing lymphadenitis; Kikuchi's disease

MeSH Terms

Arthritis
Female
Fever
Histiocytic Necrotizing Lymphadenitis
Humans
Lymphatic Diseases
Skin
Skin Manifestations

Figure

  • Fig. 1 Symmetrically distributed erythematous firm nodules measuring 8 mm in diameter are seen on both cheeks.

  • Fig. 2 (A) Patchy infiltration of mononuclear cells around skin appendages and blood vessels (H&E, ×40). (B) Infiltrating cells are composed of large, atypical lymphocytes, histiocytes with crescent-shaped nuclei, and many apoptotic cells (H&E, ×200). (C) The histiocytic cells are positive for CD68 (×100).


Reference

1. Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes. Acta Hematol Jpn. 1972. 35:379–380.
2. Fujimoto Y, Kojima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis. Naika. 1972. 30:920–927.
3. Kuo TT. Cutaneous manifestation of Kikuchi's histiocytic necrotizing lymphadenitis. Am J Surg Pathol. 1990. 14:872–876.
4. Kuo TT. Kikuchi's disease (histiocytic necrotizing lymphadenitis). A clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol. 1995. 19:798–809.
Article
5. Chae KO, Baek SC, Byun DG, Park HJ. A case of Kikuchi's disease associated with systemic lupus erythematosus. Korean J Dermatol. 2001. 39:483–486.
6. Atwater AR, Longley BJ, Aughenbaugh WD. Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations. J Am Acad Dermatol. 2008. 59:130–136.
Article
7. Felgar RE, Furth EE, Wasik MA, Gluckman SJ, Salhany KE. Histiocytic necrotizing lymphadenitis (Kikuchi's disease): in situ end-labeling, immunohistochemical, and serologic evidence supporting cytotoxic lymphocyte-mediated apoptotic cell death. Mod Pathol. 1997. 10:231–241.
8. Ohshima K, Shimazaki K, Kume T, Suzumiya J, Kanda M, Kikuchi M. Perforin and Fas pathways of cytotoxic T-cells in histiocytic necrotizing lymphadenitis. Histopathology. 1998. 33:471–478.
Article
9. Yasukawa K, Matsumura T, Sato-Matsumura KC, Takahashi T, Fujioka Y, Kobayashi H, et al. Kikuchi's disease and the skin: case report and review of the literature. Br J Dermatol. 2001. 144:885–889.
Article
10. Bataille V, Harland CC, Behrens J, Cook MG, Holden CA. Kikuchi disease (histiocytic necrotizing lymphadenitis) in association with HTLV1. Br J Dermatol. 1997. 136:610–612.
Article
11. Yen A, Fearneyhough P, Raimer SS, Hudnall SD. EBV-associated Kikuchi's histiocytic necrotizing lymphadenitis with cutaneous manifestations. J Am Acad Dermatol. 1997. 36:342–346.
Article
12. Biasi D, Caramaschi P, Carletto A, Residori C, Randon M, Friso S, et al. Three clinical reports of Kikuchi's lymphadenitis combined with systemic lupus erythematosus. Clin Rheumatol. 1996. 15:81–83.
Article
13. Dorfman RF, Berry GJ. Kikuchi's histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol. 1988. 5:329–345.
14. Spies J, Foucar K, Thompson CT, LeBoit PE. The histopathology of cutaneous lesions of Kikuchi's disease (necrotizing lymphadenitis): a report of five cases. Am J Surg Pathol. 1999. 23:1040–1047.
Article
Full Text Links
  • AD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr