Ann Dermatol.  2010 May;22(2):191-193. 10.5021/ad.2010.22.2.191.

A Case of Eccrine Spiradenoma in a Patient with Neurofibromatosis

• Park JW
• Namkoong S
• Chung J
• Jung KE
• Oh SA
• Cinn YW
• Kim MH

• KMID: 2265391
• DOI: http://doi.org/10.5021/ad.2010.22.2.191

Abstract

Neurofibromatosis is a systemic hereditary disorder with varied manifestations in bone, soft tissue, the nervous system and skin. Cutaneous manifestations of neurofibromatosis are characterized by cafe-au-lait macules, multiple neurofibromas, Lisch nodules and intertriginous freckling. Some benign or malignant tumors such as juvenile xanthogranuloma, pheochromocytoma, and malignant melanoma can accompany neurofibromatosis. But, in the English literature, no case of eccrine spiradenoma associated with neurofibromatosis has been reported. Eccrine spiradenoma is a benign uncommon neoplasm of skin adnexa. It presents as a painful, slow-growing and solitary nodule on the head or upper trunk. Here, we report a rare case of eccrine spiradenoma in a patient with neurofibromatosis.

Keyword

Eccrine spiradenoma; Neurofibromatosis

MeSH Terms

Head
Humans
Melanoma
Nervous System
Neurofibromatoses
Neurofibromatosis 1
Pheochromocytoma
Skin
Xanthogranuloma, Juvenile

Figure

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  Fig. 1 (A) Flesh-colored subcutaneous tumor of lower back. (B) Several café-au-lait macules and diffuse freckles on trunk.

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  Fig. 2 (A) Well-defined dermal nest of basaloid cells without connections to the epidermis (H&E, ×12.5). (B) Two types of epithelial cells arranged in intertwining cords with small lumina (H&E, ×400).

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