Ann Dermatol.  2010 Aug;22(3):333-336. 10.5021/ad.2010.22.3.333.

A Case of Dermatofibroma of the Upper Lip

• Lee HI
• Lee JW
• Han TY
• Li K
• Hong CK
• Seo SJ
• Song KY

• KMID: 2265371
• DOI: http://doi.org/10.5021/ad.2010.22.3.333

Abstract

Dermatofibroma (DF) is a common benign mesenchymal tumor composed of fibroblastic and histiocytic cells. It occurs anywhere on the body surface but has a propensity for the extremities. To our knowledge, DF arising in the oral cavity, especially on the lip, is quite rare. DFs of the head and neck region have been known to be most often of the cellular type and frequently recur, so a wider initial excision is recommended. Herein we report a case of DF in a 41-year-old female who presented with a deep-seated nodule on her upper lip.

Keyword

Dermatofibroma; Lip

MeSH Terms

Adult
Extremities
Female
Fibroblasts
Head
Histiocytoma, Benign Fibrous
Humans
Lip
Mouth
Neck

Figure

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  Fig. 1 Rubbery, firm, non-mobile nodule, 1.0×1.0 cm in diameter, on the upper lip with normal overlying labial mucosa and skin.

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  Fig. 2 (A) Histological findings show acanthosis of the epidermis and a poorly defined non-encapsulated deep dermal tumor (H&E, ×20). (B, C) The tumor was found to be composed of fibroblastic spindle cells in a storiform pattern, separating dermal collagen with a few histiocytes both in the superficial (B) and deep portions of the tumor (C) (H&E, ×200).

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  Fig. 3 (A) CD34 was negative in fibroblastic spindle cells and positive in vessels (×200). (B) Factor XIIIa was positive in only a few dendritic cells and negative in fibroblastic cells (×200). (C) CD68 was weak in spindle cells and strong in histiocytes (×200). (D) Smooth muscle actin (SMA) was strong in fibroblastic spindle cells (×200).

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