Ann Dermatol.  2010 Aug;22(3):262-268. 10.5021/ad.2010.22.3.262.

Comparison of Marketed Cosmetic Products Constituents with the Antigens Included in Cosmetic-related Patch Test

Affiliations
  • 1Department of Dermatology, School of Medicine, Ewha Womans University, Seoul, Korea. hychoi@ewha.ac.kr

Abstract

BACKGROUND
Currently, cosmetic series (Chemotechnique Diagnostics, Sweden) is the most widely used cosmetic-related patch test in Korea. However, no studies have been conducted on how accurately it reflects the constituents of the cosmetics in Korea.
OBJECTIVE
We surveyed the constituents of various cosmetics and compare with the cosmetic series, to investigate whether it is accurate in determining allergic contact dermatitis caused by cosmetics sold in Korea.
METHODS
Cosmetics were classified into 11 categories and the survey was conducted on the constituents of 55 cosmetics, with 5 cosmetics in each category. The surveyed constituents were classified by chemical function and compared with the antigens of cosmetic series.
RESULTS
155 constituents were found in 55 cosmetics, and 74 (47.7%) of constituents were included as antigen. Among them, only 20 constituents (27.0%) were included in cosmetic series. A significant number of constituents, such as fragrance, vehicle and surfactant were not included. Only 41.7% of antigens in cosmetic series were found to be in the cosmetics sampled.
CONCLUSION
The constituents not included in the patch test but possess antigenicity are widely used in cosmetics. Therefore, the patch test should be modified to reflect ingredients in the marketed products that may stimulate allergies.

Keyword

Allergic contact dermatitis; Cosmetic products; Cosmetics; Ingredients; Patch test

MeSH Terms

Cosmetics
Dermatitis, Allergic Contact
Hypersensitivity
Korea
Patch Tests
Cosmetics

Reference

1. Kohl L, Blondeel A, Song M. Allergic contact dermatitis from cosmetics. Retrospective analysis of 819 patch-tested patients. Dermatology. 2002. 204:334–337.
2. Emmons WW, Marks JG Jr. Immediate and delayed reactions to cosmetic ingredients. Contact Dermatitis. 1985. 13:258–265.
Article
3. Engasser PG. Cosmetics and contact dermatitis. Dermatol Clin. 1991. 9:69–80.
Article
4. Eiermann HJ, Larsen W, Maibach HI, Taylor JS. North American Contact Dermatitis Group. Prospective study of cosmetic reactions: 1977-1980. J Am Acad Dermatol. 1982. 6:909–917.
Article
5. Adams RM, Maibach HI. A five-year study of cosmetic reactions. J Am Acad Dermatol. 1985. 13:1062–1069.
Article
6. de Groot AC. Contact allergy to cosmetics: causative ingredients. Contact Dermatitis. 1987. 17:26–34.
Article
7. Eun HC, Kwon OS, Seo KI, Youn CS, Han WS, Suh DH. Review of the patch test results in patients with the cosmetic contact dermatitis. Korean J Dermatol. 1999. 37:1009–1016.
8. Scheman A. Adverse reactions to cosmetic ingredients. Dermatol Clin. 2000. 18:685–698.
Article
9. Nielsen NH, Linneberg A, Menné T, Madsen F, Frølund L, Dirksen A, et al. Allergic contact sensitization in an adult Danish population: two cross-sectional surveys eight years apart (The Copenhagen Allergy Study). Acta Derm Venereol. 2001. 81:31–34.
Article
10. de Groot AC, Bruynzeel DP, Bos JD, van der Meeren HL, van Joost T, Jagtman BA, et al. The allergens in cosmetics. Arch Dermatol. 1988. 124:1525–1529.
Article
11. Goossens A, Beck MH, Haneke E, McFadden JP, Nolting S, Durupt G, et al. Adverse cutaneous reactions to cosmetic allergens. Contact Dermatitis. 1999. 40:112–113.
Article
12. Lee JH, Park HJ, Lee JY, Kim HO, Cho BK, Kim CW. Study of the patch tests results in patients with contact dermatitis due to cosmetics. Korean J Dermatol. 2005. 43:599–605.
13. Penchalaiah K, Handa S, Lakshmi SB, Sharma VK, Kumar B. Sensitizers commonly causing allergic contact dermatitis from cosmetics. Contact Dermatitis. 2000. 43:311–313.
14. Wolf R, Wolf D, Tüzün B, Tüzün Y. Contact dermatitis to cosmetics. Clin Dermatol. 2001. 19:502–515.
Article
15. Rastogi SC. Analytical control of preservative labelling on skin creams. Contact Dermatitis. 2000. 43:339–343.
Article
16. Larsen WG. How to test for fragrance allergy. Cutis. 2000. 65:39–41.
17. Schnuch A, Uter W, Geier J, Lessmann H, Frosch PJ. Contact allergy to farnesol in 2021 consecutively patch tested patients. Results of the IVDK. Contact Dermatitis. 2004. 50:117–121.
Article
18. Malten KE, van Ketel WG, Nater JP, Liem DH. Reactions in selected patients to 22 fragrance materials. Contact Dermatitis. 1984. 11:1–10.
Article
19. Buckley DA, Wakelin SH, Seed PT, Holloway D, Rycroft RJ, White IR, et al. The frequency of fragrance allergy in a patch-test population over a 17-year period. Br J Dermatol. 2000. 142:279–283.
Article
20. Guin JD, Berry VK. Perfume sensitivity in adult females. A study of contact sensitivity to a perfume mix in two groups of student nurses. J Am Acad Dermatol. 1980. 3:299–302.
21. Larsen WG, Maibach HI. Fragrance contact allergy. Semin Dermatol. 1982. 1:85–90.
22. Ortiz KJ, Yiannias JA. Contact dermatitis to cosmetics, fragrances, and botanicals. Dermatol Ther. 2004. 17:264–271.
Article
23. van Oosten EJ, Schuttelaar ML, Coenraads PJ. Clinical relevance of positive patch test reactions to the 26 EU-labelled fragrances. Contact Dermatitis. 2009. 61:217–223.
Article
24. Roed-Petersen J, Hjorth N. Contact dermatitis from antioxidants. Br J Dermatol. 1976. 94:233–241.
Article
25. White IR, Lovell CR, Cronin E. Antioxidants in cosmetics. Contact Dermatitis. 1984. 11:265–267.
Article
26. Bazzano C, de Angeles S, Kleist G, Macedo N. Allergic contact dermatitis from topical vitamins A and E. Contact Dermatitis. 1996. 35:261–262.
Article
27. Matsumura T, Nakada T, Iijima M. Widespread contact dermatitis from tocopherol acetate. Contact Dermatitis. 2004. 51:211–212.
Article
28. Schauder S, Ippen H. Contact and photocontact sensitivity to sunscreens. Review of a 15-year experience and of the literature. Contact Dermatitis. 1997. 37:221–232.
29. Hannuksela M, Kousa M, Pirilä V. Allergy to ingredients of vehicles. Contact Dermatitis. 1976. 2:105–110.
Article
30. Conti A, Manzini BM, Schiavi ME, Motolese A. Sensitization to white petrolatum used as a vehicle for patch testing. Contact Dermatitis. 1995. 33:201–202.
Article
31. Hannuksela M, Kousa M, Pirilä V. Contact sensitivity to emulsifiers. Contact Dermatitis. 1976. 2:201–204.
Article
32. Larsen WG, Jackson EM, Barker MO, Bednarz RM, Engasser PG, O'Donoghue MN, et al. AAD Advisory Board, CTFA Task Force on Cosmetics. A primer on cosmetics. J Am Acad Dermatol. 1992. 27:469–484.
Article
33. Preston PW, Finch TM. Allergic contact dermatitis from glycerin in a moisturizing cream. Contact Dermatitis. 2003. 49:221–222.
Article
34. Sugiura M, Hayakawa R. Contact dermatitis due to 1,3-butylene glycol. Contact Dermatitis. 1997. 37:90.
Article
35. Orton DI, Wilkinson JD. Cosmetic allergy: incidence, diagnosis, and management. Am J Clin Dermatol. 2004. 5:327–337.
36. Magerl A, Heiss R, Frosch PJ. Allergic contact dermatitis from zinc ricinoleate in a deodorant and glyceryl ricinoleate in a lipstick. Contact Dermatitis. 2001. 44:119–121.
Article
37. Fisher AA. Allergic cheilitis due to castor oil in lipsticks. Cutis. 1991. 47:389–390.
38. Hasan T, Rantanen T, Alanko K, Harvima RJ, Jolanki R, Kalimo K, et al. Patch test reactions to cosmetic allergens in 1995-1997 and 2000-2002 in Finland--a multicentre study. Contact Dermatitis. 2005. 53:40–45.
Article
39. Hausen BM, Wollenweber E. Propolis allergy. (III). Sensitization studies with minor constituents. Contact Dermatitis. 1988. 19:296–303.
Full Text Links
  • AD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr