Ann Dermatol.  2013 Nov;25(4):475-478. 10.5021/ad.2013.25.4.475.

Kaposi Sarcoma in a Patient with Chronic Renal Failure Undergoing Dialysis

• Lee D
• Chun JS
• Hong SK
• Kang MS
• Seo JK
• Koh JK
• Sung HS

• KMID: 2265061
• DOI: http://doi.org/10.5021/ad.2013.25.4.475

Abstract

Kaposi sarcoma (KS) is a multicentric proliferative vascular tumor involving the skin and other organs. Human herpesvirus 8 (HHV-8) has been detected in KS lesions and is considered the putative causative agent of KS. The relationship between chronic renal failure, HHV-8, and KS is not clear. KS appears to develop in association with renal transplantation, but is unlikely with dialysis, and there have been few reports on this. Here, we report the case of a 51-year-old man, who underwent peritoneal dialysis to treat chronic renal failure, and presented with multiple brownish plaques on his soles. On histopathological examination, abnormally proliferated vessels, vascular slits, and spindle-shaped cells were seen in the dermis. Immunohistochemical staining for HHV-8 was positive. This case is another example in which factors other than immunosuppression contributed to the development of KS, due to activation of HHV-8.

Keyword

Chronic kidney failure; Dialysis; Human herpesvirus 8; Kaposi sarcoma

MeSH Terms

Dermis
Dialysis*
Herpesvirus 8, Human
Humans
Immunosuppression
Kidney Failure, Chronic*
Kidney Transplantation
Middle Aged
Peritoneal Dialysis
Sarcoma, Kaposi*
Skin

Figure

• 

  Fig. 1 (A) A 50-year-old man had a symptomatic hyperpigmented patches along the arches of both feet. (B) There were reddish-brown patches, edema, and crusts on both shins and some hyperpigmented crusted plaques on both knees.

• 

  Fig. 2 (A) The biopsy specimen of the sole showed abnormally proliferated and dilated vessels, and vascular slits in the dermis (H&E, ×40). (B) Fascicles of spindle cells intermingled with numerous jagged vascular spaces that were filled with red blood cells (H&E, ×100). (C) Immunohistochemical staining for HHV-8 was positive (HHV-8 stain, ×100). (D) The specimen from the shin showed changes typical of stasis dermatitis, along with the proliferation of capillaries and fibroblasts, while vascular slits and a typical endothelial cells were absent (H&E, ×40). HHV-8: human herpesvirus 8.

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