Ann Dermatol.  2015 Apr;27(2):228-229. 10.5021/ad.2015.27.2.228.

Oral and Cutaneous Lichenoid Eruption with Nail Changes Due to Imatinib Treatment in a Chinese Patient with Chronic Myeloid Leukemia

Affiliations
  • 1Department of Dermatology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. yjbdoctor@163.com

Abstract

No abstract available.


MeSH Terms

Asian Continental Ancestry Group*
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
Lichenoid Eruptions*
Imatinib Mesylate

Figure

  • Fig. 1 Physical evaluation of the lichenoid drug eruption. (A) Violaceous macules and flat papules on the buttocks. (B) Large dark erythematous patches covered with thick silvery scaling on the palmaris et plantaris. (C) Erosive lesions and hemorrhagic crusts on the lips, and reticular white striations on the buccal mucosa. (D) The toenails and fingernails are thickened and yellowbrown in color.

  • Fig. 2 Histology of the lichenoid drug eruption. There is liquefied degeneration of the basal cells and exocytosis of mononuclear cells into the epidermis. There is a band-like infiltrate in the superficial dermis, which is predominantly composed of lymphocytes (H&E, ×200).


Cited by  1 articles

Nail Dystrophy in Patients with Atopic Dermatitis and Its Association with Disease Severity
Bo Young Chung, Yong Won Choi, Hye One Kim, Chun Wook Park
Ann Dermatol. 2019;31(2):121-126.    doi: 10.5021/ad.2019.31.2.121.


Reference

1. Deininger MW, O'Brien SG, Ford JM, Druker BJ. Practical management of patients with chronic myeloid leukemia receiving imatinib. J Clin Oncol. 2003; 21:1637–1647.
Article
2. Kuraishi N, Nagai Y, Hasegawa M, Ishikawa O. Lichenoid drug eruption with palmoplantar hyperkeratosis due to imatinib mesylate: a case report and a review of the literature. Acta Derm Venereol. 2010; 90:73–76.
Article
3. Lee JH, Chung JY, Jung MY, Kim CR, Park JH, Park JH, et al. Lichenoid drug eruption after low-dose imatinib mesylate treatment. Ann Dermatol. 2013; 25:500–502.
Article
4. Valeyrie L, Bastuji-Garin S, Revuz J, Bachot N, Wechsler J, Berthaud P, et al. Adverse cutaneous reactions to imatinib (STI571) in Philadelphia chromosome-positive leukemias: a prospective study of 54 patients. J Am Acad Dermatol. 2003; 48:201–206.
Article
5. Wahiduzzaman M, Pubalan M. Oral and cutaneous lichenoid reaction with nail changes secondary to imatinib: report of a case and literature review. Dermatol Online J. 2008; 14:14.
Article
Full Text Links
  • AD
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr