Korean J Med.  2012 Dec;83(6):817-822.

A Case of a Calcitonin-Secreting Pancreatic Endocrine Tumor in a Pateint with Multiple Endocrine Neoplasia Type 1

Affiliations
  • 1Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. rhmrhm@cu.ac.kr
  • 2Department of Pathology, Catholic University of Daegu School of Medicine, Daegu, Korea.

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant hereditary disorder characterized by the combined occurrence of tumors of the parathyroid gland, exocrine pancreas, and anterior pituitary gland. Calcitonin-secreting pancreatic endocrine tumors are rare, and calcitonin-secreting pancreatic endocrine tumors with MEN1 have not been reported in Korea. A 46-year-old woman was admitted for a right breast cancer operation. Abnormal blood chemistry findings were hypercalcemia and elevated calcitonin. The patient was diagnosed with a calcitonin-secreting pancreatic endocrine tumor, left thyroid papillary carcinoma, right breast invasive ductal carcinoma, a thymic carcinoid tumor, left adrenal adenoma, uterine myoma, and adenomyosis by computed tomography scan, and with pituitary macroadenoma by brain magnetic resonance imaging. We present this case with a review of the literature, because it is the first reported calcitonin-secreting pancreatic endocrine tumor with MEN 1 in Korea.

Keyword

Calcitonin; Pancreatic endocrine tumor; MEN1

MeSH Terms

Adenoma
Adenomyosis
Brain
Breast
Breast Neoplasms
Calcitonin
Carcinoid Tumor
Carcinoma, Ductal
Carcinoma, Papillary
Female
Humans
Hypercalcemia
Korea
Magnetic Resonance Imaging
Middle Aged
Multiple Endocrine Neoplasia
Multiple Endocrine Neoplasia Type 1
Myoma
Pancreas, Exocrine
Parathyroid Glands
Pituitary Gland, Anterior
Thyroid Gland
Calcitonin
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