Korean J Med.  2012 Dec;83(6):771-774.

A Case of Cholangiocarcinoma with Brain and Leptomeningeal Carcinomatosis

Affiliations
  • 1Department of Internal Medicine, Korean Cancer Center Hospital, Seoul, Korea. gooddryang@naver.com
  • 2Department of Pathology, Korean Cancer Center Hospital, Seoul, Korea.

Abstract

Cholangiocarcinoma is a malignant disease originating from the epithelium of the biliary tract, and its prognosis is dismal due to distant metastasis in its early stages. The most common metastatic sites are the intra-abdominal organs, lymph nodes, and lungs. A patient was diagnosed with intrahepatic cholangiocarcinoma and underwent surgical resection. During the follow-up period, metastases were detected at the remnant liver and both lung fields. Eleven months after resection, the patient complained of severe headache. An approximately 5-cm cystic mass was found at the left occipital lobe of the cerebrum, and metastatic malignant cells were present on cerebrospinal fluid cytology. The patient underwent whole-brain radiotherapy. We herein report a rare case of cholangiocarcinoma with cystic brain metastasis together with a review of the relevant literature.

Keyword

Cholangiocarcinoma; Cystic mass; Brain metastasis; Leptomeningeal carcinomatosis

MeSH Terms

Biliary Tract
Brain
Cerebrum
Cholangiocarcinoma
Epithelium
Follow-Up Studies
Headache
Humans
Liver
Liver Neoplasms
Lung
Lymph Nodes
Meningeal Carcinomatosis
Neoplasm Metastasis
Occipital Lobe
Prognosis
Liver Neoplasms
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