Korean J Med.  2012 Oct;83(4):525-528.

A Case of Cardiogenic Shock after Chemotherapy with 5-Fluorouracil and Leucovorin in Rectal Cancer

Affiliations
  • 1Department of Internal Medicine, Chonnam National Universtiy Medical School, Gwangju, Korea. drwookyun@jnu.ac.kr

Abstract

A 51-year-old man with rectal adenocarcinoma was admitted to hospital for neoadjuvant concurrent chemoradiotherapy. Three days after receiving 5-fluorouracil (425 mg/m2) and leucovorin (20 mg/m2) chemotherapy, the patient complained of chest pain. The patient had no history of cardiac disease. Electrocardiography showed ST segment elevation in leads II, III, and aVF, but the cardiac enzymes were normal. Transthoracic echocardiography revealed global hypokinesia with marked systolic dysfunction (ejection fraction 21.55%) and coronary angiography showed no significant stenosis. Unfortunately, he died of cardiogenic shock, despite intensive medical treatment.

Keyword

5-Fluorouracil; Cardiogenic shock; Rectal cancer

MeSH Terms

Adenocarcinoma
Chemoradiotherapy
Chest Pain
Constriction, Pathologic
Coronary Angiography
Echocardiography
Electrocardiography
Fluorouracil
Heart Diseases
Humans
Hypokinesia
Leucovorin
Middle Aged
Rectal Neoplasms
Shock, Cardiogenic
Fluorouracil
Leucovorin
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