Korean J Med.  2011 Jul;81(1):17-25.

The Effects on Nutrition, Metabolism and Infection by Proton Pump Inhibitors: Unsafe Perspective

• Cha BK
• Choi CH

Abstract

Proton pump inhibitors (PPI) are very effective drug used frequently in acid-related disorders. Long-term use of PPI is becoming increasingly common, often without appropriate indications. The debate had focused on the adverse effects related to long-term use of PPI during the last years. This article is a detailed review of the evidence on this topic, focusing on the adverse effects of long-term PPI use that have developed the greatest concern; vitamin B12 deficiency, iron deficiency, impaired calcium absorption, bony fracture, hypomagnesemia, increased susceptibility to pneumonia and enteric infections. Although PPIs have been used with a high margin of safety, the clinicians should consider reducing the dose of PPIs and reassessing the treatment duration to prevent adverse effects of PPIs.

Keyword

Proton pump inhibitors; Adverse effects

MeSH Terms

Absorption
Calcium
Iron
Pneumonia
Proton Pump Inhibitors
Proton Pumps
Protons
Vitamin B 12 Deficiency
Calcium
Iron
Proton Pump Inhibitors
Proton Pumps
Protons