Korean J Med.
2011 Oct;81(4):512-516.
A Case of Combining Intravenous Immunoglobulin and Leflunomide for BK Nephropathy
- Affiliations
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- 1Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea. sh76so@cau.ac.kr
- 2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- BK virus nephropathy has emerged as an important cause of renal allograft dysfunction. It affects 1-10% of renal transplant patients and results in significant graft dysfunction in more than 50% of cases. A reduction in the amount of immunosuppressants is not an appropriate treatment option for advanced stage BK nephropathy; therefore, other treatment strategies need to be considered such as cidofovir, leflunomide, and intravenous immunoglobulin (IVIG) in combination with reduced immunosuppression. The use of IVIG may be a valuable treatment option in patients with BK virus nephropathy. We report our experience with IVIG rescue therapy in a patient and the progression of BK nephropathy despite leflunomide therapy.
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