Allergy Asthma Respir Dis.  2013 Mar;1(1):50-54. 10.4168/aard.2013.1.1.50.

The differences of clinical profiles by house dust mite sensitization in patients with asthmatics in Soonchunhyang University Hospital cohort

Affiliations
  • 1Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. jas877@schmc.ac.kr

Abstract

PURPOSE
The majority of patients with allergic disease are highly sensitized to house dust mites (HDM). There is few data to observe sensitization rate to HDM in asthmatics in Korea. The aim of this study was to observe the differences of clinical profiles by HDM sensitization in patients with asthmatics in Soonchunhyang University Hospital (SCH) cohort.
METHODS
We recruited 2,345 asthmatic patients in SCH cohort. Lung function, body mass index and sputum and blood eosinophils, and PC20, and clinical profiles were compared by HDM sensitization.
RESULTS
Dermatophagoides farinae (Derf) and/or Dermatophagoides pteronyssinus (Derp) (+) sensitization rate was higher prevalence in male than in female. Compared with nonatopy asthmatics, Derf and/or Derp (+) asthmatics had early onset of age [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 32.5+/-0.51 vs. 36.1+/-0.88 vs. 43.1+/-0.54, P<0.05]. Derf and/or Derp (+) asthmatics had shorter duration of asthma symptom than that of nonatopy asthmatics. Derf and/or Derp (+) asthmatics had lower forced expiratory volume in one second and forced vital capacity than those of Derf and Derp (-) asthmatics. PC20 in Derf and/or Derp (+) asthmatics had lower than those of Derf and Derp (-) and nonatopy asthmatics [Derf and/or Derp (+) vs. Derf and Derp (-) vs. atopy (-); 5.4+/-0.24 mg/mL vs. 6.59+/-0.52 mg/mL vs. 7.19+/-0.33 mg/mL, P<0.05]. Blood eosinophils number in Derf and/or Derp (+) asthmatics had higher than that of nonatopy asthmatics (414.7+/-131.1 vs. 350.6+/-14.0, P<0.05). Total immunoglobulin E (IgE) in Derf and/or Derp positive asthmatics had higher than that of Derf and Derp negative and nonatopy asthmatics. There was no difference of body mass index among three groups.
CONCLUSIONS
Our data indicate that atopy asthmatics sensitized to Derf and/or Derp had early onset of age, high total IgE and airway responsiveness, and eosinophilic inflammation.

Keyword

House dust mite; Atopy; Asthma; Cohort

MeSH Terms

Asthma
Body Mass Index
Cohort Studies
Dermatophagoides farinae
Dermatophagoides pteronyssinus
Dust
Eosinophils
Female
Forced Expiratory Volume
Humans
Immunoglobulin E
Immunoglobulins
Inflammation
Korea
Lung
Male
Prevalence
Pyroglyphidae
Sputum
Vital Capacity
Dust
Immunoglobulin E
Immunoglobulins

Figure

  • Fig. 1 The prevalence of allergen sensitization. Derf, Dermatophagoides farinae; Derp, Dermatophagoides pteronyssinus.


Cited by  1 articles

Changes in skin reactivity and associated factors in patients sensitized to house dust mites after 1 year of allergen-specific immunotherapy
Jeong-Yeop Son, Mann-Hong Jung, Kwang-Wook Koh, Eun-Kee Park, Jeong-Hoon Heo, Gil-Soon Choi, Hee-Kyoo Kim
Asia Pac Allergy. 2017;7(2):82-91.    doi: 10.5415/apallergy.2017.7.2.82.


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