Korean J Nutr.  2008 Oct;41(7):594-601.

Hypolipidemic and Antioxidant Effects to Ginseng Extract (PD:PT = 1) in Apo E Null Mice

• Jang S
• Kim SS
• Lee M

Abstract

Panax ginseng C.A. Meyer (Panax ginseng) has been used for several thousand years to prolong longevity in Asian countries. Ginsenosides are the most active components isolated from ginseng and belong to damarane saponin which are separated into protopanaxadiol and protopanaxtriol. To evaluate the complex effect of ginsenoside in apo E null mice, ginseng extract were intraperioneally (i.p.) injected and provided high-cholesterol diet for 12 weeks. Ginseng extract came from were i.p. injected with dose of 100 mg/kg/day for 4 weeks in the last experimental duration. Ginseng extract used experiment was abundant Rb1, Rc, Re, and Rg1 and PD:PT ratio was 1.2. The high-cholesterol diet induced liver damage was significantly reduced by ginseng extract. Results from plasma lipid profiles and atherogenic index were improved by ginseng extracts. The GE group significantly decreased plasma TG and TC by 73% and 61% compared to apo E (-/-) group. Also ginseng extract tend to decrease lipid profiles and lipidperoxidation contents in liver and heart. Ginseng extract with an abundant amount of Rg1 significantly suppressed the apoptosis induction of cardiac tissue. In conclusion, ginseng extract (PD:PT = 1) was improved lipid profiles and anti-oxidant effects.

Keyword

panax ginseng; ginsenoside; PD:PT ratio; lipidperoxidation; lipid profile

MeSH Terms

Animals
Antioxidants
Apolipoproteins E
Apoptosis
Asian Continental Ancestry Group
Diet
Ginsenosides
Heart
Humans
Liver
Longevity
Mice
Panax
Plasma
Porphyrins
Sapogenins
Saponins
Triterpenes
Antioxidants
Apolipoproteins E
Ginsenosides
Porphyrins
Sapogenins
Saponins
Triterpenes