Korean J Obstet Gynecol.  2002 Feb;45(2):226-233.

Loss of Fhit Expression in Cervical Intraepithelial lesion and Invasive Cervical Carcinoma

Affiliations
  • 1Department of Obstetrics and Gynecology, Yeungnam University Hospital, Taegu, Korea.
  • 2Department of Pathology, Yeungnam University Hospital, Taegu, Korea.

Abstract


OBJECTIVE
The author evaluated the relationship between the loss of Fhit and prognostic factors of invasive cervical carcinomas.
METHODS
The formalin prepared tissue specimens of 64 CINs and 27 invasive cervical carcinomas patients diagnosed and treated at the department of obstetrics and gynecology, Yeungnam university hospital from June 1977 to February 2001 were obtained. And then the tissue specimens were analysed & measured by immunohistochemical methods.
RESULTS
The loss of Fhit was significantly reduced in invasive cervical carcinomas compared to CINs. But we found there is no relationships between the loss of Fhit and prognostic factors, stage, tumor marker, lymphatic spread and radiation therapy of invasive cervical carcinomas.
CONCLUSIONS
Although the loss of Fhit was not related to the precancerous lesion of cervix, we could confirm that the loss of Fhit was important in the progression of precancerous lesions to invasive cervical carcinomas.

Keyword

Fhit Expression; Cervical Intraepithelial lesion; Invasive Cervical Carcinoma

MeSH Terms

Cervix Uteri
Female
Formaldehyde
Gynecology
Humans
Obstetrics
Formaldehyde
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