Allergy Asthma Respir Dis.  2014 Sep;2(4):293-297. 10.4168/aard.2014.2.4.293.

Factors associated with serum vitamin D levels in children with recurrent wheezing less than 3 years old

Affiliations
  • 1Department of Pediatrics, Ilsin Christian Hospital, Busan, Korea. jinny198@hanmail.net
  • 2Department of Pediatrics, Dong-A University College of Medicine, Busan, Korea.
  • 3Department of Pathology, Dong-A University College of Medicine, Busan, Korea.
  • 4Department of Pediatrics, On Hospital, Busan, Korea.

Abstract

PURPOSE
We evaluated the relationship between laboratory/clinical factors and vitamin D levels in recurrent wheezers less than 3 years old.
METHODS
We retrospectively analyzed clinical data and laboratory factors (25-hydroxyvitamin D, complete blood count, C-reactive protein, glutamic oxaloacetic transaminase, glutamyl purovic transaminase, alkaline phosphatase [ALP], eosinophil counts, and serum IgE IgG, IgA, IgM) of 84 children less than 3 years who had experienced wheezing episodes at least 3 times.
RESULTS
Children in the normal group (1.4+/-0.9 years) were younger than those in the deficient (2.2+/-1.2 years) and insuffient (2.3+/-1.0 years) groups (P=0.010). Glutamyl purovic transaminase were higher in the normal group (24.5+/-19.4 IU/L) than in the deficient (16.0+/-4.7 IU/L) and insufficient (15.3+/-4.5 IU/L) groups (P=0.009). ALP were higher in the deficient (791.4+/-180.8 IU/L) and insufficient (770.4+/-251.2 IU/L) groups than in the normal group (631.9+/-127.0 IU/L, P=0.034). Total IgE levels were higher in the deficient group (171.9+/-212.1 kU/L) than in the normal group (43.7+/-58.3 kU/L, P<0.05), and the rate of sensitization to aeroallergens was higher in the insufficient group (36.1%) than in the normal group (10%, P<0.05).
CONCLUSION
Among children with recurrent wheezing less than 3 years old, low vitamin D levels may be associated with older age, total IgE, ALP level, glutamic pyruvate transaminase level, and rate of sensitization to aeroallergens.

Keyword

Vitamin D; Asthma; Wheezing; Young childhood

MeSH Terms

Alkaline Phosphatase
Aspartate Aminotransferases
Asthma
Blood Cell Count
C-Reactive Protein
Child*
Eosinophils
Humans
Immunoglobulin A
Immunoglobulin E
Immunoglobulin G
Pyruvic Acid
Respiratory Sounds*
Retrospective Studies
Vitamin D*
Alkaline Phosphatase
Aspartate Aminotransferases
C-Reactive Protein
Immunoglobulin A
Immunoglobulin E
Immunoglobulin G
Pyruvic Acid
Vitamin D

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