Korean J Obstet Gynecol.  2000 May;43(5):914-917.

A case of advanced ovarian cancer which was treated with topotecan after taxol-cisplatin treatment failed

Abstract

Ovarian cancer has the highest mortality rate among gynecologic malignancies in developed countries. Most women present with advanced disease and require a combination of surgery and chemotherapy. One patient presented with recurrent ovarian cancer was initially treated with taxol and platinum-based compounds. Although response to these agents occurred, tumor progression was evident by elevated CA 125 levels and CT findings after a period of 4 months. This patient was then treated with topotecan and exhibited a response and stopped therapy. Topotecan exhibited activity in this patient with ovarian cancer resistent to both platinum and paclitaxel. We report a case of advanced ovarian cancer which was treated with topotecan after taxol-cisplatin treatment failed.

Keyword

Topotecan; Taxol-Cisplatin; Advanced ovarian cancer
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