Korean J Obstet Gynecol.  2000 Feb;43(2):243-247.

A Comparison of Intravaginal Misoprostol and Dinoprostone for Cervical Ripening and Labor Induction in Term Pregnancy with Unfavorable Cervix

Abstract


OBJECTIVE
To compare the efficacy and safety of intravaginal administerd misoprostol and PGE2 (dinoprostone) with oxytocin for inducing labor in women with an unfavorable cervix.
METHODS
One hundred thirteen patients with indicated for labor induction and unfavorable cervix were randomly assigned and received either misoprostol 50microgram intravaginal with oxytocin intravenous injection or prostaglandin E2(dinoprostone) 3mg intravaginal with oxytocin intravenous injection.
RESULTS
Thirty-nine subjects were assigned to misoprostol with oxytocin group and 74 to the PGE2 with oxytocin group. The median interval from induction to vaginal delivery was significantly shorter in the misoprostol with oxytocin group(1274+/-496 versus 1512+/-501 minutes)(p<0.001). No significant difference between two groups were mode of delivery, neonatal and maternal outcomes.
CONCLUSION
Intravaginal misoprostol and PGE2 vaginal insert appear to be safe agents for cervical ripening and labor induction. Misoprostol is more effective than PGE2 vaginal insert with oxytocin injection.

Keyword

Misoprostol; Dinoprostone(PGE2); Oxytocin; Cervical ripening

MeSH Terms

Cervical Ripening*
Cervix Uteri*
Dinoprostone*
Female
Humans
Injections, Intravenous
Misoprostol*
Oxytocin
Pregnancy
Pregnancy*
Dinoprostone
Misoprostol
Oxytocin
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