Allergy Asthma Immunol Res.  2014 May;6(3):228-233. 10.4168/aair.2014.6.3.228.

Clinical Characteristics of Gastroallergic Anisakiasis and Diagnostic Implications of Immunologic Tests

• Chung YB
• Lee J

• KMID: 2260685
• DOI: http://doi.org/10.4168/aair.2014.6.3.228

Abstract

PURPOSE
Recent studies have used the term "gastroallergic anisakiasis" to describe incidental gastrointestinal infection with Anisakis spp. larvae, proposed as a causative agent of food hypersensitivity. However, it is unknown whether this condition represents an independent disease entity distinguishable from acute gastric anisakiasis. To better understand the role of the allergic response in Anisakis infections we examined the clinical and immunological implications of Anisakis-specific IgE.
METHODS
A prospective study was performed in a geographic region where the consumption of raw seafood is common. Case subjects who had been clinically diagnosed with gastroallergic anisakiasis were selected, along with controls who frequently ate raw seafood but had never experienced gastroallergic anisakiasis-like symptoms. Clinical and immunological features were compared based on atopic status, sensitization rates to Anisakis, and serum titer of Anisakis-specific IgE.
RESULTS
Seventeen case subjects and 135 controls were included in this study. The case subjects had experienced gastrointestinal symptoms after raw seafood ingestion, along with additional mucocutaneous, respiratory, or multisystemic symptoms. Case subjects were significantly sensitized to Anisakis excretory-secretory product and crude extract compared with controls (76.5% vs. 19.3%, P<0.001, and 88.2% vs. 30.3%, P<0.001, respectively). Anisakis-specific serum IgE titers were also significantly higher in case subjects than in controls. Both the results of skin prick tests and elevated Anisakis-specific IgE titers (>17.5 kU/L) were found to be reliable indicators for the diagnosis of gastroallergic anisakiasis.
CONCLUSIONS
Among patients presenting acute gastric anisakiasis-like symptoms, a diagnosis of gastroallergic anisakiasis may be strongly supported by a high Anisakis-specific IgE titer.

Keyword

Anisakis; food hypersensitivity; immediate hypersensitivity; skin tests; immunoglobulin E; nematode Infections

MeSH Terms

Anisakiasis*
Anisakis
Diagnosis
Eating
Food Hypersensitivity
Humans
Hypersensitivity, Immediate
Immunoglobulin E
Immunologic Tests*
Larva
Nematode Infections
Prospective Studies
Seafood
Skin
Skin Tests
Immunoglobulin E

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