Allergy Asthma Immunol Res.  2010 Apr;2(2):141-143. 10.4168/aair.2010.2.2.141.

A Case of Occupational Rhinitis Caused by Rice Powder in the Grain Industry

Affiliations
  • 1Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea. hspark@ajou.ac.kr

Abstract

Rice is the major staple food in a large part of the world, especially in Asia. Hypersensitivity reactions to rice are rare. Moreover, cases of occupational allergies induced by inhalation of rice powder are uncommon. We report a 31-year-old male with work-related rhinitis and conjunctivitis symptoms caused by occupational exposure to rice powder in the grain industry. He showed positive responses to rice extracts on a skin prick test, and a high level of serum specific IgE to rice was detected by ELISA. Occupational rhinitis was confirmed by a nasal provocation test with rice extracts. An IgE ELISA inhibition test showed cross-creativity between rice and various grass pollen extracts. These findings suggest that the inhalation of rice powder can induce IgE-mediated occupational rhino-conjunctivitis, which may be derived from cross-reactivity to major grass pollens.

Keyword

Occupational rhinitis; rice; grass pollen; cross-reactivity; immediate hypersensitivity

MeSH Terms

Adult
Asia
Edible Grain
Conjunctivitis
Enzyme-Linked Immunosorbent Assay
Humans
Hypersensitivity
Hypersensitivity, Immediate
Immunoglobulin E
Inhalation
Male
Nasal Provocation Tests
Occupational Exposure
Poaceae
Pollen
Rhinitis
Skin
Immunoglobulin E

Figure

  • Fig. 1 Result of the skin prick test showing a positive response to rice extracts (C, normal saline; H, histamine).

  • Fig. 2 (A) Specific IgE ELISA to rice extracts in sera from the patient and 10 non-atopic healthy controls. Horizontal bars indicate the positive cutoff value determined from the mean ± 3 SD of the absorbance value of normal controls. (B) Result of the rice IgE-ELISA inhibition test with additions of rice and grass pollen extracts including rye, timothy, and orchard grasses and Dermatophagoides pteronyssinus.

  • Fig. 3 The serial changes in the eosinophil cationic protein (ECP) level presented as the ratio to total protein in nasal lavage fluids, and symptom scores during the nasal provocation test with rice extracts (1 mg/mL).


Reference

1. Orhan F, Sekerel BE. A case of isolated rice allergy. Allergy. 2003. 58:456–457.
2. Lezaun A, Igea JM, Quirce S, Cuevas M, Parra F, Alonso MD, Martin JA, Cano MS. Asthma and contact urticaria caused by rice in a housewife. Allergy. 1994. 49:92–95.
3. Moscato G, Siracusa A. Rhinitis guidelines and implications for occupational rhinitis. Curr Opin Allergy Clin Immunol. 2009. 9:110–115.
4. Malo JL, Lemiere C, Desjardins A, Cartier A. Prevalence and intensity of rhinoconjunctivitis in subjects with occupational asthma. Eur Respir J. 1997. 10:1513–1515.
5. Monzon S, Lombardero M, Perez-Camo I, Saenz D, Lasanta J. Allergic rhinoconjunctivitis after ingestion of boiled rice. J Investig Allergol Clin Immunol. 2008. 18:487–488.
6. Melillo G, Bonini S, Cocco G, Davies RJ, de Monchy JG, Frolund L, Pelikan Z. EAACI provocation tests with allergens. Report prepared by the European Academy of Allergology and Clinical Immunology Subcommittee on provocation tests with allergens. Allergy. 1997. 52:1–35.
7. Litvyakova LI, Baraniuk JN. Nasal provocation testing: a review. Ann Allergy Asthma Immunol. 2001. 86:355–364.
8. Choi GS, Park HJ, Hur GY, Choi SJ, Shin SY, Ye YM, Park HS. Vascular endothelial growth factor in allergen-induced nasal inflammation. Clin Exp Allergy. 2009. 39:655–661.
9. Moscato G, Vandenplas O, Van Wijk RG, Malo JL, Perfetti L, Quirce S, Walusiak J, Castano R, Pala G, Gautrin D, De Groot H, Folletti I, Yacoub MR, Siracusa A. EAACI position paper on occupational rhinitis. Respir Res. 2009. 10:16.
10. Gautrin D, Ghezzo H, Malo JL. Rhinoconjunctivitis, bronchial responsiveness, and atopy as determinants for incident non-workrelated asthma symptoms in apprentices exposed to high-molecular-weight allergens. Allergy. 2003. 58:608–615.
11. Sen MM, Adhikari A, Gupta-Bhattacharya S, Chanda S. Airborne rice pollen and pollen allergen in an agricultural field: aerobiological and immunochemical evidence. J Environ Monit. 2003. 5:959–962.
12. McCurdy SA, Ferguson TJ, Goldsmith DF, Parker JE, Schenker MB. Respiratory health of California rice farmers. Am J Respir Crit Care Med. 1996. 153:1553–1559.
13. Kumar R, Srivastava P, Kumari D, Fakhr H, Sridhara S, Arora N, Gaur SN, Singh BP. Rice (Oryza sativa) allergy in rhinitis and asthma patients: a clinico-immunological study. Immunobiology. 2007. 212:141–147.
14. Xu H, Theerakulpisut P, Goulding N, Suphioglu C, Singh MB, Bhalla PL. Cloning, expression and immunological characterization of Ory s 1, the major allergen of rice pollen. Gene. 1995. 164:255–259.
15. Enrique E, Ahrazem O, Bartra J, Latorre MD, Castello JV, de Mateo JA, Montoya E, Malek T, Barber D, Salcedo G. Lipid transfer protein is involved in rhinoconjunctivitis and asthma produced by rice inhalation. J Allergy Clin Immunol. 2005. 116:926–928.
16. Asero R, Amato S, Alfieri B, Folloni S, Mistrello G. Rice: another potential cause of food allergy in patients sensitized to lipid transfer protein. Int Arch Allergy Immunol. 2007. 143:69–74.
17. Miadonna A, Milazzo N, Gibelli S, Salmaso C, Lorini M, Tedeschi A. Nasal response to a single antigen challenge in patients with allergic rhinitis - inflammatory cell recruitment persists up to 48 hours. Clin Exp Allergy. 1999. 29:941–949.
18. Kramer MF, Jordan TR, Klemens C, Hilgert E, Hempel JM, Pfrogner E, Rasp G. Factors contributing to nasal allergic late phase eosinophilia. Am J Otolaryngol. 2006. 27:190–199.
19. Rondon C, Fernandez J, Lopez S, Campo P, Dona I, Torres MJ, Mayorga C, Blanca M. Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. J Allergy Clin Immunol. 2009. 124:1005.e1–1011.e1.
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