Allergy Asthma Immunol Res.  2010 Oct;2(4):254-259. 10.4168/aair.2010.2.4.254.

Effects of Smoking Cessation on Airflow Obstruction and Quality of Life in Asthmatic Smokers

  • 1Asthma and Allergy Research Group, Korea.
  • 2Division of Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
  • 3Division of Allergy and Respiratory Diseases, Soonchunhyang University Seoul Hospital, Seoul, Korea.
  • 4Division of Allergy and Respiratory Diseases, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
  • 5Division of Allergy and Respiratory Diseases, Soonchunhyang University Gumi Hospital, Gumi, Korea.


Smoking elicits airway inflammation and airflow obstruction in patients with asthma, even after smoking cessation. The aim of this study was to examine the effects of smoking cessation on lung function and quality of life (QOL) in asthmatic patients.
Thirty-two patients with asthma who were active smokers were recruited. After education on the effects of smoking on asthma, 22 patients continued to smoke, and 10 quit smoking. All patients were treated with inhaled fluticasone propionate (1 mg/day) for 3 months. We compared forced expiratory volume in 1 s (FEV1), FEV1/forced vital capacity (FVC), forced expiratory flow between 25 and 75% FVC (FEF(25-75%)), and scores on a QOL questionnaire at baseline, 1, 2, and 3 months.
Quitters showed a greater percent change in FEV1 (19.1+/-6.3 vs. 7.9+/-2.4%, P=0.024) and FEV1/FVC (6.5+/-4.14 vs. 3.5+/-1.5%, P=0.05) than smokers. Both quitters and smokers showed improved QOL scores after 1, 2, and 3 months of fluticasone treatment.
Patients with asthma who quit smoking showed less airway obstruction, suggesting that smoking cessation is crucial in the management of asthma.


Smoking; asthma; lung function; quality of life
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