Korean J Nutr.  2007 Jul;40(5):413-418.

Effect of Chronical Ethanol Ingestion on the Levels of Fatty Acid Ethyl Esters (FAEEs) and Lipid Peroxidation in Rat Tissues

• Kim MS
• Kim SN
• Park HS

Abstract

The present study was designed to observe the effect of chronically ingested ethanol on the level of fatty acid ethyl esters (FAEEs), which is a non-oxidative metabolite of ethanol metabolism in tissues, and its correlation to the status of oxidative stress in rats. Forty male Sprague Dawley rats weighing 145 - 155 g were divided into 2 groups, Control and EtOH. All rats were fed Lieber-DeCarli liquid diet for 4 weeks by pair-feeding. An isocaloric maltose dextrin was added in replace of 50 g ethanol (36%kcal) in the control diet. Chronically ingested ethanol significantly increased the content of FAEEs in pancreas and liver, but not in brain. The level of 2-thiobarbituric acid reactive substances (TBARS) was significantly increased, but alpha-tocopherol level was significantly decreased in pancreas and liver. However, the levels of TBARS and alpha-tocopherol in brain were not significantly affected by ethanol ingestion. Therefore, chronically ingested ethanol might cause tissue damage by increasing the levels of FAEEs and TBARS and dissipating more alpha-tocopherol in tissues.

Keyword

chronical ethanol ingestion; non-oxidative metabolism; fatty acid ethyl esters; oxidative stress

MeSH Terms

alpha-Tocopherol
Animals
Brain
Control Groups
Diet
Eating*
Esters*
Ethanol*
Humans
Lipid Peroxidation*
Liver
Male
Maltose
Metabolism
Oxidative Stress
Pancreas
Rats*
Rats, Sprague-Dawley
Thiobarbituric Acid Reactive Substances
Esters
Ethanol
Maltose
Thiobarbituric Acid Reactive Substances
alpha-Tocopherol