Allergy Asthma Immunol Res.  2013 Jul;5(4):232-238. 10.4168/aair.2013.5.4.232.

Rhinitis Patients With Sputum Eosinophilia Show Decreased Lung Function in the Absence of Airway Hyperresponsiveness

Affiliations
  • 1Department of Internal medicine, SMG-SNU Boramae Medical Center, Seoul, Korea.
  • 2Department of Internal medicine, Seoul National University College of Medicine, Seoul, Korea. shcho@snu.ac.kr
  • 3Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.
  • 4Department of Internal Medicine, Korean Armed Forces Capital Hospital, Seongnam, Korea.
  • 5Division of Allergy and Clinical Immunology, Department of Internal Medicine, Kangwon National University College of Medicine, Chuncheon, Korea.
  • 6Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

PURPOSE
Sputum eosinophilia is observed frequently in patients with rhinitis. Sputum eosinophilia in patients with non-asthmatic allergic rhinitis has been suggested to be related to nonspecific airway hyperresponsiveness (AHR). However, the clinical significance of sputum eosinophilia in patients with non-asthmatic rhinitis without AHR has not been determined. We conducted a retrospective study examining the influence of sputum eosinophilia in patients with non-asthmatic rhinitis without AHR on pulmonary function and expression of fibrosis-related mediators.
METHODS
Eighty-nine patients with moderate-to-severe perennial rhinitis without AHR were included. All underwent lung function tests (forced expiratory volume in 1 second [FEV1] and forced vital capacity [FVC]), skin tests to inhalant allergens, methacholine bronchial challenge tests, and hypertonic saline-induced sputum to determine eosinophil counts. Sputum mRNA levels for transforming growth factor-beta (TGF-beta), matrix metalloproteinase-9 (MMP-9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were also examined. Patients were divided into two groups according to the presence of sputum eosinophilia (> or =3%, eosinophilia-positive [EP] and <3%, eosinophilia-negative [EN] groups).
RESULTS
FEV1 was significantly lower (P=0.04) and FEV1/FVC tended to be lower (P=0.1) in the EP group than in the EN group. In sputum analyses, the MMP-9 mRNA level (P=0.005) and the ratio of MMP-9 to TIMP-1 expression (P=0.01) were significantly higher in the EP group than in the EN group. There was no significant difference in TGF-beta mRNA expression between the two groups.
CONCLUSIONS
Sputum eosinophilia in patients with moderate-to-severe perennial rhinitis without AHR influenced FEV1 and the expression pattern of fibrosis-related mediators.

Keyword

Sputum; eosinophil; rhinitis; forced expiratory volume; matrix metalloproteinase-9
Full Text Links
  • AAIR
Share
  • Twitter
  • Facebook
Copyright © 2020 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr