Allergy Asthma Immunol Res.  2015 Jan;7(1):3-13. 10.4168/aair.2015.7.1.3.

Clinical Application of Exhaled Nitric Oxide Measurements in a Korean Population

Affiliations
  • 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. shcho@snu.ac.kr
  • 2Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 3Allergy TF, Department of Immunology and Pathology, Korea National Institute of Health, Cheongwon, Korea.
  • 4Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.
  • 5Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • 6Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Suwon, Korea.
  • 7Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
  • 8Department of Pediatrics, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 9Department of Pediatrics, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 10Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
  • 11Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea.
  • 12Department of Pediatrics, Hae-undae Paik Hospital, Inje University College of Medicine, Busan, Korea.
  • 13Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
  • 14Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.
  • 15Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea.
  • 16Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
  • 17Department of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjhong@amc.seoul.kr

Abstract

Nitric oxide (NO) is a biologic mediator of various physiologic functions. Recent evidence suggests the clinical utility of fractional exhaled NO (FeNO) as a biomarker for assessing asthma and other respiratory diseases. FeNO methodologies have been recently standardized by international research groups and subsequently validated in several Korean population studies. Normal ranges for FeNO have been reported for various ethnic groups, and the clinical utility has been widely evaluated in asthma and various respiratory diseases. Based on current evidence including most of Korean population data, this position paper aims to introduce the methodological considerations, and provide the guidance for the proper clinical application of FeNO measurements in Korean populations.

Keyword

Exhaled nitric oxide; reference value; guideline; position paper; asthma

MeSH Terms

Asthma
Ethnic Groups
Humans
Nitric Oxide*
Reference Values
Nitric Oxide

Figure

  • Figure Schematic presentation of the distribution of fractional exhaled nitric oxide levels in an adult Korean population: (A) males and (B) females. The data were obtained from the studies conducted by Jo et al.45


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