Korean J Med.
2010 Mar;78(3):386-390.
A case of myeloid neoplasm with the PDGFRB rearrangement and eosinophilia
- Affiliations
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- 1Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul, Korea. hyejin@kcch.re.kr
- 2Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
- 3Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
Abstract
- Myeloid neoplasm with the platelet-derived growth factor receptor beta (PDGFRB) rearrangement is a myeloproliferative neoplasm. Patients with this disease often have prominent eosinophilia or monocytosis and the presence of t(5;12)(q31~33;p12) or a variant translocation with expression of an ETV6-PDGFRB fusion gene or the PDGFRB rearrangement. We report an 82-year-old woman with a myeloid neoplasm, with the PDGFRB rearrangement, who presented with a dry cough, eosinophilia and thrombocytosis. The chromosome study of the bone marrow showed 46,XX,ins(1;5)(q22;q33q13.3), and fluorescence in situ hybridization (FISH) analysis revealed rearrangement of the PDGFRB gene. The patient was successfully treated with low-dose imatinib.
MeSH Terms
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Aged, 80 and over
Benzamides
Bone Marrow
Cough
Eosinophilia
Female
Fluorescence
Humans
In Situ Hybridization
Piperazines
Pyrimidines
Receptor, Platelet-Derived Growth Factor beta
Receptors, Platelet-Derived Growth Factor
Thrombocytosis
Imatinib Mesylate
Benzamides
Piperazines
Pyrimidines
Receptor, Platelet-Derived Growth Factor beta
Receptors, Platelet-Derived Growth Factor
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