Korean J Med.
2011 Apr;80(4):405-407.
Proton Pump Inhibitors with Clopidogrel: Is There Benefit or Harm?
- Affiliations
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- 1Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
Abstract
- The treatment of acute coronary syndromes involves a combination of antiplatelet therapies. Proton pump inhibitors (PPIs) are often recommended for prophylaxis of gastrointestinal bleeding. Recent studies have shown that the cardiovascular harmful effects of the combination therapy with these two drugs cause serious results in patients with acute coronary syndrome. However, the data on this subject, especially on the clinical outcomes, are conflicting. Based on the available data, the decision to prescribe a PPI to a patient on clopidogrel should be done after evaluation of the cardiovascular risk and the gastrointestinal benefit. Further prospective randomized trials are needed to jump to the conclusions.
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