Korean J Med.  2011 Jun;80(Suppl 2):S227-S232.

A Case of Hyperkalemic Periodic Paralysis Induced by Diabetic Nephropathy

Affiliations
  • 1Department of Internal Medicine, Good Gang-An Hospital, Busan, Korea. lyk59@medimail.co.kr
  • 2Department of Neurology, Good Gang-An Hospital, Busan, Korea.

Abstract

Hyperkalemic periodic paralysis is characterized by episodic flaccid paralysis of the skeletal muscles due to an increase in serum potassium concentrations. Primary hyperkalemic periodic paralysis is caused by point mutations in SCN4A, encoding a voltage-gated skeletal muscle sodium channel. However, hyperkalemia-related diseases, such as renal failure, adrenal insufficiency, hypoaldosteronism, and chronic diuretic use, can induce secondary hyperkalemic periodic paralysis. Diagnosis of this disease is based on clinical features, nerve conduction studies, and a DNA sequence analysis. In cases of diagnostic uncertainty, a provocation test can be used to ensure the correct diagnosis. Here, we report a case of secondary hyperkalemic periodic paralysis with hyperkalemia that was induced by diabetic nephropathy, and review the relevant literature.

Keyword

Diabetic Nephropathy; Hyperkalemic Periodic; Paralysis

MeSH Terms

Adrenal Insufficiency
Diabetic Nephropathies
Dietary Sucrose
Hyperkalemia
Hypoaldosteronism
Muscle, Skeletal
Neural Conduction
Paralysis
Paralysis, Hyperkalemic Periodic
Point Mutation
Potassium
Renal Insufficiency
Sequence Analysis, DNA
Sodium Channels
Uncertainty
Dietary Sucrose
Potassium
Sodium Channels
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