Korean J Med.
2011 Jun;80(Suppl 2):S227-S232.
A Case of Hyperkalemic Periodic Paralysis Induced by Diabetic Nephropathy
- Affiliations
-
- 1Department of Internal Medicine, Good Gang-An Hospital, Busan, Korea. lyk59@medimail.co.kr
- 2Department of Neurology, Good Gang-An Hospital, Busan, Korea.
Abstract
- Hyperkalemic periodic paralysis is characterized by episodic flaccid paralysis of the skeletal muscles due to an increase in serum potassium concentrations. Primary hyperkalemic periodic paralysis is caused by point mutations in SCN4A, encoding a voltage-gated skeletal muscle sodium channel. However, hyperkalemia-related diseases, such as renal failure, adrenal insufficiency, hypoaldosteronism, and chronic diuretic use, can induce secondary hyperkalemic periodic paralysis. Diagnosis of this disease is based on clinical features, nerve conduction studies, and a DNA sequence analysis. In cases of diagnostic uncertainty, a provocation test can be used to ensure the correct diagnosis. Here, we report a case of secondary hyperkalemic periodic paralysis with hyperkalemia that was induced by diabetic nephropathy, and review the relevant literature.