Korean J Med.  2008 Dec;75(6):607-615.

Pathophysiology of gallstone

Affiliations
  • 1Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.

Abstract

Gallstones form as the culmination of a complex series of events that results in precipitation of insoluble substances including cholesterol or bilirubin in the gallbladder. Bile formation is essential for lipid digestion and the removal of excess cholesterol from the body either by direct excretion or after conversion to bile acids. Gallstones occur when insoluble lipids and inorganic salts secreted by the liver cannot be solubilized as they normally are in bile by the detergent properties of bile salts. For this to occur, metabolic events must take place to produce bile that contains excess amounts of either cholesterol or bilirubin (supersaturation), both of which are relatively insoluble in aqueous solution. Additionally, physical factors must allow rapid nucleation within the residence time of bile in the biliary tree.

Keyword

Gallstone; Bile; Pathophysiology

MeSH Terms

Bile
Bile Acids and Salts
Bilirubin
Cholesterol
Detergents
Digestion
Gallbladder
Gallstones
Hypogonadism
Liver
Mitochondrial Diseases
Ophthalmoplegia
Salts
Bile Acids and Salts
Bilirubin
Cholesterol
Detergents
Hypogonadism
Mitochondrial Diseases
Ophthalmoplegia
Salts
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